Standardised concentrations of morphine infusions for nurse/patient-controlled analgesia use in children

BMC Anesthesiology
Asia N RashedStephen Tomlin

Abstract

Standardizing concentrations of intravenous infusions enables pre-preparation and is effective in improving patient safety by avoiding large deviations from the prescribed concentration that can occur when infusions are made individually in wards and theatres. The use of pre-prepared morphine standardized concentration infusions for paediatric nurse/patient-controlled analgesia (N/PCA) has not been previously investigated. We aimed to establish, implement and evaluate standardized concentrations of morphine in pre-filled syringes (PFS) for use in paediatric N/PCA. Concentrations of morphine in PFS for N/PCA were identified that accommodated dosage variation across a 1-50 kg weight range. The use of infusions in PFS was implemented and evaluated using mixed methods involved direct observation of healthcare professionals (HCPs), focus groups and failure mode and effects analysis, a HCP survey and medication incident reports analysis. Standardized concentrations, 3 mg, 10 mg and 50 mg morphine in 50 mL sodium chloride 0.9%, delivered prescribed continuous and bolus doses using programmable smart pumps with variable infusion rates. During the implementation, 175 morphine pre-prepared infusions were administered to 157 children (9.4...Continue Reading

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Oct 7, 2014·European Journal of Hospital Pharmacy. Science and Practice·Asia N RashedStephen Tomlin
Jun 24, 2016·The Journal of Pharmacy and Pharmacology·Sara Arenas-LópezShane M Tibby
Aug 10, 2016·International Journal of Clinical Pharmacy·Asia N RashedCate Whittlesea
Aug 16, 2016·The Journal of Pharmacy and Pharmacology·Joanne PerkinsSara Arenas-Lopez

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Citations

Jun 18, 2021·Journal of Pediatric Nursing·David Sharp, Adrianna Jaffrani

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