Standardised evaluation of medicine acceptability in paediatric population: reliability of a model

The Journal of Pharmacy and Pharmacology
Thibault ValletAmeziane Aoussat

Abstract

Our novel tool to standardise the evaluation of medicine acceptability was developed using observational data on medicines use measured in a paediatric population included for this purpose (0-14 years). Using this tool, any medicine may be positioned on a map and assigned to an acceptability profile. The present exploration aimed to verify its statistical reliability. Permutation test has been used to verify the significance of the relationships among measures highlighted by the acceptability map. Bootstrapping has been used to demonstrate the accuracy of the model (map, profiles and scores of acceptability) regardless of variations in the data. Lastly, simulations of enlarged data sets (×2; ×5; ×10) have been built to study the model's consistency. Permutation test established the significance of the meaningful pattern identified in the data and summarised in the map. Bootstrapping attested the accuracy of the model: high RV coefficients (mean value: 0.930) verified the mapping stability, significant Adjusted Rand Indexes and Jaccard coefficients supported clustering validity (with either two or four profiles), and agreement between acceptability scores demonstrated scoring relevancy. Regarding enlarged data sets, these indica...Continue Reading

References

Apr 8, 2014·International Journal of Pharmaceutics·Piotr Kozarewicz
Jun 30, 2016·International Journal of Pharmaceutics·Smita Salunke, Catherine Tuleu

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Citations

Aug 14, 2020·Pharmaceutics·Thibault ValletVincent Boudy
Nov 21, 2020·Drug Discovery Today·Catherine TuleuFabrice Ruiz
Sep 5, 2021·Archives of Disease in Childhood·Ebiowei Samuel F OrubuAnthony Nunn
Nov 21, 2021·Archives of Disease in Childhood·Varsha PokharkarSmita Salunke

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