Standardization criteria for an ischemic surgical model of acute hepatic failure in pigs

Biomaterials
Martin NieuwoudtSchalk Van der Merwe

Abstract

The establishment of a reliable large animal model of acute hepatic failure (AHF) is critical for the evaluation of supportive therapies such as bioartificial liver support systems (BALSS). Large animal surgical models bear some resemblance to the clinical syndrome of AHF in humans. However, these are inherently complex and are predisposed to inter-individual variation. The development of considerable skill is required and no precise standardization criteria for such models have been defined as yet. This study investigates a surgically induced ischemic model of AHF in 15 female Landrace pigs. A large set of systemic and biochemical variables were measured. The absolute values of systemic variables during the surgery and the rates of change of the biochemical variables following the surgery were correlated with the duration of survival of each animal. A multivariate prognosis was revealed, with several variables simultaneously determining survival. Those of importance in the surgical period included the duration of portal occlusion, the pulse rate during this time, the total blood lost, the mean arterial pressure and the body temperature after the procedure. In the post-surgical period the rates of change of blood ammonia, branc...Continue Reading

Citations

Aug 22, 2013·Journal of Materials Science. Materials in Medicine·Shichang ZhangYingjie Wang
May 5, 2009·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Martin NieuwoudtSchalk W van der Merwe
Jul 4, 2012·The Veterinary Journal·Rajagopal N AravalliClifford J Steer
Oct 10, 2006·Artificial Organs·Oleksandr Seleverstov, Augustinus Bader
May 13, 2008·Cell Transplantation·Takeshi YuasaNaoya Kobayashi
Jun 2, 2017·World Journal of Gastroenterology : WJG·Guo-Lin HeYi Gao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.