Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Michael NavitskyMichael D Devous

Abstract

Klunk et al. recently proposed a means of standardizing quantitation of amyloid burden from positron emission tomography scans to a common Centiloid scale, and we have applied that method to florbetapir. Florbetapir and Pittsburgh compound B scans were acquired for 46 mixed clinical presentation subjects within 18 ± 20 days. Florbetapir and Pittsburgh compound B cortical standardized uptake value ratio (SUVr) values were well correlated for both standard Centiloid (R2 = 0.894) and Avid (R2 = 0.901) volume of interests (VOIs). The methods of Klunk et al. were applied to establish a conversion first from florbetapir SUVr values obtained using standard Centiloid VOIs to Centiloids and then from Avid VOIs (Joshi et al.) to Centiloids. The equation for conversion of florbetapir SUVr from Avid VOIs to the Centiloid scale was as follows: Florbetapir Centiloids = 183 × SUVrAvid - 177. The threshold that discriminated neuropathologically verified none or sparse versus moderate to frequent plaques in autopsy-confirmed data is 24.1 Centiloids. These findings may allow improved tracer-independent amyloid quantitation.

References

Mar 3, 2004·Annals of Neurology·William E KlunkBengt Långström
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Jul 21, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Natalie NelissenRik Vandenberghe
May 27, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Dean F WongMichael J Pontecorvo
Dec 15, 2010·Methods in Molecular Biology·Victor L VillemagneChristopher C Rowe
Jan 20, 2011·JAMA : the Journal of the American Medical Association·Christopher M ClarkUNKNOWN AV45-A07 Study Group
Jun 1, 2011·Seminars in Nuclear Medicine·Shankar Vallabhajosula
Feb 15, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Abhinay D JoshiUNKNOWN Florbetapir F 18 Study Investigators
Nov 21, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Susan M LandauUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jan 31, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Keith A JohnsonUNKNOWN Amyloid Imaging Taskforce
Feb 12, 2013·Journal of Nuclear Medicine Technology·Christopher C Rowe, Victor L Villemagne
Dec 3, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·William E KlunkMark A Mintun
Dec 3, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mark E SchmidtUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 7, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Susan M LandauWilliam J Jagust
Sep 5, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Abhinay D JoshiMichael D Devous
Feb 26, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christopher C RoweVictor L Villemagne
Apr 1, 2007·PET Clinics·Olivier RoussetHabib Zaidi

❮ Previous
Next ❯

Citations

Mar 9, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Yi SuTammie L S Benzinger
May 19, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Vincent DoréSusan De Santi
Dec 14, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Soo Hyun ChoSang Won Seo
Jul 11, 2020·Human Brain Mapping·Irina JelistratovaMichel J Grothe
Apr 21, 2020·Brain Communications·Shannon L RisacherAndrew J Saykin
Mar 7, 2020·Alzheimer's Research & Therapy·Sanka AmadoruChristopher C Rowe
Sep 6, 2020·European Journal of Nuclear Medicine and Molecular Imaging·J L EbenauB N M van Berckel
Oct 20, 2020·JAMA Neurology·David S KnopmanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jan 9, 2021·Brain and Cognition·Lou RizzoloFabienne Collette
Jan 20, 2021·Radiology·Victor L VillemagneBart N M van Berckel
Nov 18, 2020·Neurology·Michelle E FarrellUNKNOWN Alzheimer's Disease Neuroimaging Initiative and the Harvard Aging Brain Study
Nov 21, 2020·Journal of Alzheimer's Disease : JAD·Warren BarkerRanjan Duara
Jan 24, 2021·Seminars in Nuclear Medicine·Natasha KrishnadasChristopher C Rowe
Feb 23, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Stephen Loucian LoweJohn R Sims
Feb 23, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jennifer A ZimmerJohn R Sims
Feb 23, 2021·NeuroImage·Seung Kwan KangUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 8, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Tensho YamaoHiroshi Matsuda
Apr 3, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jordi PeguerolesUNKNOWN Australian Imaging, Biomarkers and Lifestyle Research Group
Apr 14, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Adam J Schwarz
May 12, 2021·Alzheimer's Research & Therapy·Sarah K RoyseUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Nov 13, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andre MuellerAndrew W Stephens
May 25, 2021·Frontiers in Aging Neuroscience·Weiqi BaoYiyun Henry Huang
Sep 23, 2021·Nature Reviews. Neurology·Eric McDadeStefan F Lichtenthaler
Oct 7, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Giordana Salvi de SouzaAna Maria Marques da Silva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Dana L TudorascuAnn D Cohen
European Journal of Nuclear Medicine and Molecular Imaging
Chloe HuttonAlzheimer’s Disease Neuroimaging Initiative
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Christopher C RoweVictor L Villemagne
© 2022 Meta ULC. All rights reserved