Standardization of antifungal susceptibility testing

The Journal of Antimicrobial Chemotherapy
M G Cormican, M A Pfaller

Abstract

The application of in-vitro antifungal susceptibility testing to clinical research and to the guidance of antifungal therapy has been limited by a lack of reproducibility and uncertain clinical relevance. As a result of studies of the identified variables impacting on in-vitro susceptibility results, the National Committee for Clinical Laboratory Standards have proposed a standardized antifungal susceptibility test method M27-P. The degree of intra- and inter-laboratory reproducibility which can be achieved with this method have been defined in multi-laboratory collaborative studies. More convenient methods (microdilution broth and stable gradient technology) have been evaluated relative to the proposed standard method and the potential for a similar process with a disc diffusion method is apparent. A modification of this standard method for susceptibility testing of filamentous fungi appears promising. The existence of a standardized method and of alternative methods with a defined relationship to the proposed standard, facilitates meaningful analysis of published studies addressing the issue of clinical relevance of antifungal susceptibility testing. As a result of this process, correlation of MICs determined in vitro with cl...Continue Reading

Citations

Oct 12, 2000·Diagnostic Microbiology and Infectious Disease·B PosteraroG Fadda
Dec 21, 2002·Diagnostic Microbiology and Infectious Disease·Birgit WillingerMichael Seibold
Jan 10, 2002·Infectious Disease Clinics of North America·M A Pfaller, W L Yu
Feb 7, 2001·Journal of Clinical Microbiology·J MeletiadisP E Verweij
Jan 31, 2002·The Annals of Pharmacotherapy·Fawziah MarraRobert D Levy
Jun 1, 1997·Antimicrobial Agents and Chemotherapy·P SandvenJ Lassen

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