Standardization of Cassia spectabilis with respect to authenticity, assay and chemical constituent analysis.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Angeline ToreyLachimanan Yoga Latha

Abstract

Quality control standardizations of the various medicinal plants used in traditional medicine is becoming more important today in view of the commercialization of formulations based on these plants. An attempt at standardization of Cassia spectabilis leaf has been carried out with respect to authenticity, assay and chemical constituent analysis. The authentication involved many parameters, including gross morphology, microscopy of the leaves and functional group analysis by Fourier Transform Infrared (FTIR) spectroscopy. The assay part of standardization involved determination of the minimum inhibitory concentration (MIC) of the extract which could help assess the chemical effects and establish curative values. The MIC of the C. spectabilis leaf extracts was investigated using the Broth Dilution Method. The extracts showed a MIC value of 6.25 mg/mL, independent of the extraction time. The chemical constituent aspect of standardization involves quantification of the main chemical components in C. spectabilis. The GCMS method used for quantification of 2,4-(1H,3H)-pyrimidinedione in the extract was rapid, accurate, precise, linear (R(2) = 0.8685), rugged and robust. Hence this method was suitable for quantification of this compon...Continue Reading

References

May 29, 2004·Journal of Natural Products·Claudio ViegasMarcos N Eberlin
Nov 13, 2008·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·S SangethaS Suryani

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Citations

Oct 1, 2011·Asian Pacific Journal of Tropical Biomedicine·S KumarO M Prakash
Jan 1, 2012·Asian Pacific Journal of Tropical Biomedicine·Dinesh KumarAnkit Gupta
Oct 23, 2013·Asian Pacific Journal of Tropical Biomedicine·Savitri ShresthaDhananjaya Bhadrapura Lakkappa
Feb 13, 2016·Journal of Traditional and Complementary Medicine·Angeline ToreySreenivasan Sasidharan
Jul 26, 2011·Journal of Ethnopharmacology·Stanley N WambuguStephen G Kiama
Aug 31, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Subramanion L JothySreenivasan Sasidharan

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