PMID: 3770052Aug 1, 1986Paper

Standardization of steroid receptor assays in human breast cancer--IV. Long-term within- and between-laboratory variation of estrogen and progesterone receptor assays

European Journal of Cancer & Clinical Oncology
A Koenders, S M Thorpe

Abstract

One batch of lyophilized calf uterine cytosol was analyzed for estrogen and progesterone receptor (ER and PgR, respectively) content by 12 members of the EORTC Receptor Group on three different occasions over a total study period of 1 yr: One vial was included with each of 20 consecutive batches of routine tumor analyses between December 1983 and May 1984. Two vials were simultaneously assayed between July and August 1984 (within-run variation). One vial was analyzed at the end of 1984 (November-December). The overall mean ER and PgR values did not change systematically over the total study period of 1 yr. Within the various laboratories, the between-run variations of both ER and PgR assays were considerable and differed from one institution to another (7-26%). For both ER and PgR measurements the average within-run (n = 2) and between-run (n = 20) coefficients of variation were similar (8-9% and 16-17%, respectively). Comparison of the results from multiple sequential assays (c.v. = 12.9%) with those from single assays (c.v. = 21.2%) showed that about 60% of the between-laboratory variance in ER could be explained on the basis of the between-run variance. With regard to PgR analysis, however, the between-laboratory variance de...Continue Reading

References

May 12, 1979·Lancet·T CookeK Griffiths
Nov 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Oct 1, 1983·European Journal of Cancer & Clinical Oncology·J F StewartJ L Hayward
Jan 1, 1983·Breast Cancer Research and Treatment·T Koenders, T J Benraad
Oct 1, 1983·European Journal of Cancer & Clinical Oncology·A Koenders, S M Thorpe
Nov 14, 1981·British Medical Journal·R CrotonK Griffiths

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Citations

Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S RomainH Magdelenat
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·J P PeyratA Demaille
Jul 8, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F RévillionJ P Peyrat
Feb 1, 1992·Journal of Clinical Pathology·F T BosmanM Rousch
Jul 1, 1994·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·M R BarboucheP M Martin
Dec 1, 1989·Pathology, Research and Practice·D Ricketts, R C Coombes
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B QuesnelJ P Peyrat
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S M Thorpe
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S RomainP M Martin
May 1, 1987·European Journal of Cancer & Clinical Oncology·G Leclercq
Jul 1, 1988·European Journal of Cancer & Clinical Oncology·S M Thorpe, C Rose
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S RomainP M Martin
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Roux-DossetoP M Martin
Mar 16, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N KromanH T Mouridsen
Oct 1, 1989·Breast Cancer Research and Treatment·M GrimauxH Magdelénat
Feb 15, 1990·International Journal of Cancer. Journal International Du Cancer·M GrimauxH Magdelenat
Oct 1, 1994·International Journal of Cancer. Journal International Du Cancer·S RomainP M Martin
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne Chotteau-LelièvreJean-Philippe Peyrat
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Françoise RévillionJean-Philippe Peyrat

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