PMID: 7017901Jan 1, 1980Paper

Standardization of the APTT test. Current status

Scandinavian Journal of Haematology. Supplementum
L Poller

Abstract

The partial thromboplastin time (PTT) which is used as an overall measure of the intrinsic clotting system, is the commonest coagulation test employed in routine laboratories apart from the prothrombin time. The main functions of the test are: - 1. to screen intrinsic coagulation defects; 2. to control heparin administration; 3. in the control of oral anticoagulant treatment. Many different preparations of phospholipid of human, animal and vegetable origin are used as PTT reagents. In addition, different activators, incubation times, concentrations of calcium chloride and test dilutions of plasma and phospholipid are recommended for routine laboratory use. The need to standardise both reagents and technique has been emphasised in many reports. To meet the need for a reference preparation for the PTT test, a large batch of phospholipid material of human brain origin, designated 71/25, was prepared in the National (UK) Reference Laboratory in lyophilised form in 1971 and proposed as a provisional international reference material. This primary master preparation has been used to calibrate subsequent batches of secondary reference preparations distributed to hospitals in the UK and overseas. Results of a number of collaborative stu...Continue Reading

References

Sep 1, 1976·Thrombosis Research·D P ThomasV V Kakkar
May 1, 1977·American Journal of Clinical Pathology·G A ShapiroJ E Wilson
Jun 28, 1973·The New England Journal of Medicine·N Fiumara
Dec 1, 1974·American Journal of Clinical Pathology·A L Babson, S R Babson
Dec 1, 1972·Journal of Clinical Pathology·L Poller, J M Thomson
Apr 1, 1973·American Journal of Clinical Pathology·C SibleyR J Wood
Jan 1, 1980·British Journal of Haematology·L PollerK F Yee

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Citations

Jan 26, 2021·Frontiers in Pediatrics·Alison B Nair, Robert I Parker

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