Standardization of the red cell product

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Joseph D Sweeney

Abstract

Red cell products are currently sourced from whole blood and apheresis donations. Whole blood derived red cell products may show up to a two-fold variation in red cell content (potency); apheresis derived red cell products are currently more standardized to a red cell content of 180 ml and with much less variation, approximately 6%. Whole blood collections can be modified to produce a more standardized red cell content and apheresis collections can also be modified to increase variability. The advantage of a standardized red cell product lies in the greater degree of predictability of clinical outcome for any predefined recipient. This, in turn, could result in an alteration in physician prescribing practices, avoiding over-transfusion, especially in low volume recipients. An alternative would be to measure and label the potency of each red cell product, allowing some degree of recipient defined product choice by the transfusion service. The current situation where red cell products are prescribed in non-standard 'units' is outdated and unscientific.

References

May 5, 1998·Transfusion Medicine Reviews·H G Klein
Apr 20, 2001·Transfusion Medicine Reviews·A Tinmouth, I Chin-Yee
Jun 26, 2001·Transfusion Medicine·UNKNOWN Council of Europe Expert Committee in Blood Transfusion Study Group on Pathogen Inactivation of Labile Blood Components
Jan 5, 2002·Transfusion·J R HessT J Greenwalt
Jul 31, 2002·Transfusion·John R HessTibor J Greenwalt
Jun 10, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Mark A Popovsky

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Citations

May 11, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Olga Meltem AkayEren Gunduz
Nov 1, 2011·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·O Erhabor, T C Adias
May 6, 2009·Transfusion·Joseph SweeneyJonathan Kurtis
Dec 15, 2010·Transfusion Medicine·H ReikvamUNKNOWN BEST collaborative
Jul 25, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Raj Bharath RudrappanLekshmi Mohan

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