Standardized Comparison of Selected Physiological Controllers for Rotary Blood Pumps: In Vitro Study

Artificial Organs
Anastasios PetrouMarianne Schmid Daners

Abstract

Various physiological controllers for left ventricular assist devices (LVADs) have been developed to prevent flow conditions that may lead to left ventricular (LV) suction and overload. In the current study, we selected and implemented six of the most promising physiological controllers presented in literature. We tuned the controllers for the same objectives by using the loop-shaping method from control theory. The in vitro experiments were derived from literature and included different preload, afterload, and contractility variations. All experiments were repeated with an increased or decreased contractility from the baseline pathological circulation and with simulated sensor drift. The controller performances were compared with an LVAD operated at constant speed (CS) and a physiological circulation. During preload variations, all controllers resulted in a pump flow change that resembled the cardiac output response of the physiological circulation. For afterload variations, the response varied among the controllers, whereas some of them presented a high sensitivity to contractility or sensor drift, leading to LV suction and overload. In such cases, the need for recalibration of the controllers or the sensor is indicated. Prel...Continue Reading

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Citations

Jul 29, 2018·Annals of Biomedical Engineering·Anastasios PetrouMarianne Schmid Daners
Jul 12, 2018·IEEE Transactions on Bio-medical Engineering·Anastasios PetrouMarianne Schmid Daners
Dec 1, 2018·Journal of Medical Engineering & Technology·Yuhui ShiYubing Shi
Jan 27, 2019·Artificial Organs·Paul S Malchesky
Sep 15, 2019·Artificial Organs·Eric L WuShaun D Gregory
Sep 8, 2020·Advanced Healthcare Materials·Seraina A DualMarianne Schmid Daners
Aug 30, 2019·Journal of Medical Engineering & Technology·Yubing Shi, Hongyi Yang
Oct 24, 2020·Expert Review of Medical Devices·Andrew F StephensRobert F Salamonsen
Sep 28, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Maria RocchiKrzysztof Zieliński
Apr 27, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Marianne Schmid DanersSeraina A Dual

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