Standardized Duplex Ultrasound-Based Protocol for Early Diagnosis of Transplant Renal Artery Stenosis: Results of a Single-Institution Retrospective Cohort Study

BioMed Research International
Vincenzo Li MarziSergio Serni

Abstract

Transplant renal artery stenosis (TRAS) is the most frequent vascular complication after kidney transplantation (KT) and has been associated with potentially reversible refractory hypertension, graft dysfunction, and reduced patient survival. The aim of the study is to describe the outcomes of a standardized Duplex Ultrasound- (DU-) based screening protocol for early diagnosis of TRAS and for selection of patients potentially requiring endovascular intervention. We retrospectively reviewed our prospectively collected database of KT from January 1998 to select patients diagnosed with TRAS. The follow-up protocol was based on a risk-adapted, dynamic subdivision of eligible KT patients in different risk categories (RC) with different protocol strategies (PS). Of 598 patients included in the study, 52 (9%) patients had hemodynamically significant TRAS and underwent percutaneous angioplasty (PTA) and stent placement. Technical and clinical success rates were 97% and 90%, respectively. 7 cases of restenosis were recorded at follow-up and treated with re-PTA plus stenting. Both DU imaging and clinical parameters improved after stent placement. Prospective high-quality studies are needed to test the efficacy and safety of our protocol ...Continue Reading

References

Dec 25, 2003·Journal of the American Society of Nephrology : JASN·Simona BrunoPiero Ruggenenti
Jun 10, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Adina VoiculescuBernd Grabensee
Jul 11, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Katsuhiro KobayashiAlan M Cohen
Jul 1, 2008·Transplantation Proceedings·P PappasA Kostakis
Dec 17, 2009·Techniques in Vascular and Interventional Radiology·Wade HedegardMark G Davies
Jan 22, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mahendra Mangray, John P Vella
Aug 11, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M T AbateE P Nord
Dec 21, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M WillicombeD Taube
Nov 25, 2014·Seminars in Nephrology·Jay I Lakkis, Matthew R Weir
Feb 24, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D M BiedermanR A Lookstein
Feb 26, 2015·Clinical Kidney Journal·Wei ChenGraciela O DeBoccardo
Jul 21, 2015·Journal of Ultrasound·Antonio GranataPasquale Fatuzzo
Jan 11, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Simon R KnightLiset H M Pengel

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Citations

Nov 14, 2018·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Graziano VignoliniSergio Serni
Sep 5, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Riccardo CampiSergio Serni
Dec 3, 2020·Frontiers in Surgery·Graziano VignoliniRiccardo Campi
Aug 18, 2021·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·David Eugenio Hinojosa-GonzalezEduardo Flores-Villalba

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Methods Mentioned

BETA
percutaneous transluminal angioplasty

Software Mentioned

SPSS

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