Abstract
Several anhepatic pig models were developed in the past. Most models suffer from short anhepatic survival times due to insufficient postoperative intensive care unit (ICU) management. The aim of this study was to analyze anhepatic survival time under standardized intensive care therapy in a pig model. Eight pigs underwent total hepatectomy after Y-graft interposition between the infrahepatic vena cava and the portal vein to the suprahepatic vena cava. An intracranial probe was inserted for intracranial pressure (ICP) monitoring. Animals received pressure-controlled ventilation under deep narcosis. Vital parameters were continuously recorded. Urinary output, blood gas analysis, haemoglobin, hematocrit, serum electrolytes, lactate, and glucose were monitored hourly, and creatinine, prothrombin time, international normalised ratio, and serum albumin were monitored every 8 hours. Sodium chloride solution 0.9%, hydroxyethyl starch 6%, fresh frozen plasma, and erythrocyte units were used for volume substitution, and norepinephrine was used to prevent severe hypotension. Serum electrolytes and acid-base balance were corrected as required. Antibiotic prophylaxis with ceftriaxon was given daily, as well as furosemide, to maintain diures...Continue Reading
References
Jun 1, 1991·Digestive Diseases and Sciences·J Terblanche, R Hickman
Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·D Henne-BrunsB Kremer
Jan 1, 1987·The Journal of Surgical Research·G H de GrootJ Bruinvels
Apr 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A Diaz-BuxoB Gordon
Jan 25, 2000·The Journal of Surgical Research·S BenoistB Nordlinger
Apr 13, 2000·International Journal of Experimental Pathology·T M Rahman, H J Hodgson
May 18, 2000·Artificial Organs·Y KamoharaT Kanematsu
Jan 3, 2001·Transplantation Proceedings·F VistoliF Mosca
May 18, 2001·Intensive Care Medicine·T Rahman, H Hodgson
Jan 31, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F Filipponi, F Mosca
Feb 1, 2002·Transplantation·Meindert N SosefThomas M van Gulik
May 7, 2002·Critical Care Medicine·Mireille DesilleBruno Clément
Jan 20, 2004·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M N Sosef, T M van Gulik
Jan 21, 2004·The Journal of Surgical Research·Fiona G CourtGuy J Maddern
Jul 3, 2004·Surgery·Nils R FrühaufChristoph E Broelsch
Feb 9, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·R LadurnerA Königsrainer
May 11, 2006·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Steffen MitznerReinhart Schmidt
May 11, 2006·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Robert A F M ChamuleauMaarten-Paul van de Kerkhove
Jul 11, 2006·Cell Transplantation·Jörg C Gerlach
Sep 25, 2007·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·K KnubbenA Königsrainer
Apr 1, 2010·BMC Gastroenterology·Philip N NewsomeJohn N Plevris
Citations
Jul 16, 2011·BMC Gastroenterology·Karolin ThielChristian Thiel
Mar 23, 2011·Toxicology Letters·Christian ThielMartin Schenk
Dec 1, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Harendra AroraTomasz Kozlowski
Mar 23, 2017·World Journal of Gastroenterology : WJG·Karolin ThielChristian Thiel
Jan 1, 2014·Hepatology International·Karolin ThielChristian Thiel
Jun 2, 2017·World Journal of Gastroenterology : WJG·Guo-Lin HeYi Gao