Standardized mitotic counts in breast cancer. Evaluation of the method

Pathology, Research and Practice
Y U CollanE Wisse

Abstract

Twenty-one pathologists and technicians participated in a study evaluating the variation present in mitotic counts for prognostication of breast cancer. The participants counted the mitotic figures in 20 breast cancer samples from ten high power fields (mitotic activity index, MAI, giving the results in mitotic figures per 10 fields) and also made a correction for field size and area fraction of the neoplastic epithelium to get the standardized mitotic index (volume fraction corrected mitotic index, or M/VV index, giving the result in mitotic figures per square mm of neoplastic epithelium). The difference in variation between the two methods was not big, but the standardized mitotic index (SMI) showed consistently smaller variation among all participants and different subgroups. Experienced pathologists had the highest variation in mitotic counts, and specially trained technicians, the lowest. The efficiency of the mitotic counts in grading (the grading efficiency) was used to evaluate the mitotic counts. In groups without special training for mitotic counts the mean grading efficiency was lower (experienced and training pathologists both on average had the potential to grade 88% of the cases correctly) than in the group specia...Continue Reading

References

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·S AaltomaaK Syrjänen
Jul 1, 1990·Human Pathology·K DonhuijsenV Budach
Jun 1, 1994·Pathology, Research and Practice·H P KujariN B Atkin
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Citations

Feb 19, 1999·Journal of Clinical Pathology·P J van DiestJ P Baak
Nov 1, 1996·Pathology, Research and Practice·T Kuopio, Y Collan
Dec 29, 1998·Human Pathology·P KronqvistY Collan
Oct 10, 2013·BioMed Research International·Jamela BoderYrjö Collan
Jan 30, 2003·Annals of Medicine·Päivi J JalavaYrjo U I Collan
Jan 26, 2000·British Journal of Cancer·R P GroenendijkT Wobbes
Jan 5, 2002·Journal of the National Cancer Institute. Monographs·M G Daidone, R Silvestrini

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