Standardized sweat chloride analysis for the diagnosis of cystic fibrosis in Korea

The Korean journal of laboratory medicine
Sue Jung KimJeong-Ho Kim

Abstract

Cystic fibrosis is a chronic progressive autosomal recessive disorder caused by the CFTR gene mutations. It is quite common in Caucasians, but very rare in Asians. Sweat chloride test is known to be a screening test for the cystic fibrosis due to the fact that electrolyte levels in sweat are elevated in patients. In this study, sweat chloride levels in Korean population were measured and analyzed by using standardized pilocarpine iontophoresis sweat chloride test. The sweat chloride test was performed in 47 patients referred to Yondong Severance Hospital from August, 2001 to April, 2007 and 41 healthy volunteers. The sweat chloride tests were conducted according to the CLSI C34-A2 guideline using pilocarpine iontophoresis method, and the chloride concentrations in sweat were measured by mercurimetric titration. Four patients showed sweat chloride concentrations higher than 60 mmol/L. Reference interval was calculated as 1.4-44.5 mmol/L by analysis of the results of healthy volunteers (n=41). Four patients who exhibited high sweat chloride levels, had characteristic clinical features of cystic fibrosis and their diagnoses were confirmed either by repeated sweat chloride test or genetic analysis. Standardized sweat chloride test ...Continue Reading

References

Apr 1, 1973·Archives of Disease in Childhood·J D HardyP N Polycarpou
Oct 1, 1980·The American Journal of Medicine·P B DavisP A Di Sant'Agnese
Mar 15, 1996·Statistics in Medicine·M R KosorokP M Farrell
May 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·Y YamashiroY Ohtsuka
May 15, 1998·The Journal of Pediatrics·B J Rosenstein, G R Cutting
Aug 9, 2002·The New England Journal of Medicine·Joshua D GromanGarry R Cutting
Apr 25, 2006·Journal of Paediatrics and Child Health·Richard MackayJean Kirk
Jun 17, 2006·Journal of Korean Medical Science·Won-Jung KohSeong Yong Lim
Apr 5, 2007·American Journal of Respiratory and Critical Care Medicine·Frank J Accurso
May 1, 2007·Clinics in Chest Medicine·Steven D Strausbaugh, Pamela B Davis
Jul 1, 1946·American Journal of Diseases of Children·D H ANDERSEN, R G HODGES

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Citations

Jan 18, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·So Yeon YangHyun Jung Yoon
Jul 23, 2011·The Korean journal of laboratory medicine·Haiyoung JungJong-Won Kim

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