PMID: 7939390Jan 1, 1994Paper

Standardizing and reporting results from Mg2+ ISEs, with some notes on sample handling

Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
N Fogh-Andersen, O Siggaard-Andersen

Abstract

Mg2+ by ion-selective electrode (ISE) is a direct measure of the reactivity of magnesium ions in plasma, which may be clinically and physiologically more relevant than the concentration of total magnesium. The Mg(2+)-ISE will build up an electric potential which exactly matches the chemical potential of Mg2+ in the sample. Chemical potential (= chemical work per unit of Mg2+) has no absolute value and is difficult to visualize. The results must be standardized, either to the magnesium concentration in a protein-free calibrator or to the concentration of total magnesium in plasma. The constant factor relationship will assure identical clinical discrimination, no matter how the Mg(2+)-ISE results are reported. The general opinion of a conference held in Orlando, Florida in March of 1993 was to define free Mg2+ in plasma as the concentration of magnesium in a saline standard with the same magnesium activity as the sample, and report it in SI units (mmol/L). The small differences in liquid junction potential and water concentration will provide a value for free Mg2+ in plasma of approximately 103% of the true concentration, or 96% of the true molality. Differences between plasma and interstitial fluid and Donnan equilibria across t...Continue Reading

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