Abstract
Stanniocalcin-1 (STC1) is a secreted glycoprotein hormone and highly expressed in various types of human malignancies. Although evidence points to the role of STC1 in human cancers, the clinical significance of STC1 expression in glioma has not been established. Here, we investigated the relationship between STC1 expression and clinicopathological significance in glioma. In our study, we selected 60 cases of different grades glioma tissues to detect the expression of STC1. Data showed that the mRNA and protein levels of STC1 in high-grade glioma tissues were significantly higher than that in low-grade tissues. The results of double immunofluorescent staining disclosed STC1 distribution in vascular endothelial cells and the cytoplasm in high-grade glioma, but almost distributed only in vascular endothelial cells in low-grade glioma. By immunohistochemistry, we got the same results and the expression of STC1 has significant difference in high-grade gliomas and low-grade gliomas. Furthermore, the results of Kaplan-Meier analysis indicated that cases with high STC1expression had significantly worse overall survival than those with low level of STC1. These results suggested that STC1 may be a valuable biomarker in diagnosing maligna...Continue Reading
References
May 12, 1998·The American Journal of Physiology·A Wagner, J Boos
Aug 26, 1998·The American Journal of Pathology·K Z ZhangL C Andersson
Jan 3, 2001·Brain Research·A M FranzénL C Andersson
Sep 12, 2002·The Journal of Biological Chemistry·Christopher R McCuddenGraham F Wagner
Sep 25, 2003·Endocrine-related Cancer·A C-M ChangR R Reddel
Apr 13, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hiroko Ohgaki
Aug 20, 2005·Endocrinology·Ho Y YeungChris K C Wong
Dec 7, 2005·The American Journal of Surgical Pathology·Martin HasselblattWerner Paulus
Nov 10, 2006·Molecular and Cellular Endocrinology·Joseph P EllardGraham F Wagner
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Jan 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Markus HuttererAxel Ullrich
Sep 3, 2009·Annals of the New York Academy of Sciences·Giuseppina BasiniFrancesca Grasselli
Dec 8, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shinya OhkouchiDarwin J Prockop
Oct 3, 2012·Cancer Research·Prakash ChinnaiyanRobert Gillies
Mar 8, 2014·The Journal of Pathology·Guang-Ning YanDe-Yu Guo
Apr 15, 2014·Proteomics·Jong Hyuk YoonTaehoon G Lee
Nov 14, 2014·Clinical & Experimental Metastasis·Andy C-M ChangRobin L Anderson
Citations
May 22, 2016·Molecular Neurobiology·Peiliang GengHoujie Liang
Apr 6, 2017·Molecular Oncology·Zahid NawazKumaravel Somasundaram
Jul 1, 2017·Cancer Biology & Therapy·Elīna ZandbergaAija Linē
Sep 10, 2017·Pathology Oncology Research : POR·Linsen FengWeixing Hu
Feb 1, 2019·Journal of Neuro-oncology·Junichi SakataEiji Kohmura
Jan 17, 2020·PLoS Biology·Nathan BasistyBirgit Schilling
May 26, 2017·Oncotarget·Xi PanGuancheng Li
May 20, 2020·Expert Review of Proteomics·Nathan BasistyBirgit Schilling
May 30, 2020·Journal of Cellular and Molecular Medicine·Fangyu ZhaoYupei Zhao
Aug 23, 2019·Molecular Medicine Reports·Yan Xiong, Qibai Wang
Oct 1, 2020·Cancer Biotherapy & Radiopharmaceuticals·Jian WenYing Xiao
Jan 27, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Zhiwen LiuLiyu He
Jan 17, 2020·Scientific Reports·Mark A CalhounJessica O Winter
Oct 9, 2020·Journal of Oncology·Yuchao Liu, Shihua Yin
Mar 30, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kristen D BrantleyTimothy L Lash
Jun 25, 2020·Cell Reports·Tamihiro KamataCatrin Pritchard
Apr 27, 2021·Technology in Cancer Research & Treatment·Xiaotao SuChao Qin
Aug 17, 2021·Frontiers in Immunology·Alexandru TatomirHorea Rus
Oct 16, 2021·Pathology Oncology Research : POR·Masuma KhatunTerhi T Piltonen