Stanniocalcin-1 secretion and receptor regulation in kidney cells

American Journal of Physiology. Renal Physiology
Olga SazonovaGraham F Wagner

Abstract

Kidney collecting duct principal cells are the main source of stanniocalcin-1 (STC-1) production and secretion. From there, the hormone targets thick ascending limb and distal convoluted tubule cells, as well as collecting duct cells. More specifically, STC-1 targets their mitochondria to exert putative antiapoptotic effects. Two distal tubule cell lines serve as models of STC-1 production and/or mechanism of action. Madin-Darby canine kidney-1 (MDCK-1) cells mimic collecting duct cells in their synthesis of STC-1 ligand and receptor, whereas inner medullary collecting duct-3 (IMCD-3) cells respond to additions of STC-1 by increasing their respiration rate. In the present study, MDCK cell STC-1 secretion was examined under normal and hypertonic conditions, vectorally, and in response to hormones and signal transduction pathway activators/inhibitors. STC-1 receptor regulation was monitored in both cell lines in response to changing ligand concentration. The results showed that NaCl-induced hypertonicity had concentration-dependent stimulatory effects on STC-1 secretion, as did the PKC activator TPA. Calcium and ionomycin were inhibitory, whereas calcium receptor agonists had no effect. Angiotensin II, aldosterone, atrial natriur...Continue Reading

References

Apr 1, 1990·The American Journal of Physiology·T NakanishiM B Burg
Oct 30, 1989·Biochimica Et Biophysica Acta·Y NakazatoT Saruta
Mar 11, 1988·The American Journal of Physiology·H S Chase, S M Wong
May 1, 1982·The Journal of Cell Biology·D A HerzlingerG K Ojakian
Nov 2, 1995·Nature·P ScheiffeleK Simons
Aug 11, 1995·Molecular and Cellular Endocrinology·A C ChangR R Reddel
Feb 1, 1995·Kidney International·C C WillingerW Pfaller
Aug 1, 1993·Journal of the American Society of Nephrology : JASN·H SchramekW Pfaller
Jan 1, 1993·The American Journal of Physiology·A YamauchiJ S Handler
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·H S OlsenG F Wagner
Feb 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G F WagnerJ L Renfro
Feb 1, 1997·The American Journal of Physiology·H KitamuraE Imai
Apr 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M Mello-AiresM Oliveira-Souza
Oct 15, 1998·The Journal of Endocrinology·C K WongG F Wagner
Mar 11, 2000·American Journal of Physiology. Renal Physiology·D Sheikh-HamadY Yang
Jun 3, 2000·American Journal of Physiology. Renal Physiology·S K WooH M Kwon
Oct 29, 2000·American Journal of Physiology. Renal Physiology·M Oliveira-Souza, M De Mello-Aires
Jan 9, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S E Stasko, G F Wagner
Feb 19, 2002·Molecular and Cellular Endocrinology·Dennis P RadmanGraham F Wagner
Feb 28, 2002·Endocrinology·Robin VargheseGabriel E Dimattia
Aug 24, 2002·Endocrinology·Ellen H FilvaroffDorothy M French
Jan 28, 2005·Kidney International·Kathi JamesGraham F Wagner
Feb 25, 2005·Vitamins and Hormones·Mary E Gerritsen, Graham F Wagner
Sep 10, 2005·American Journal of Physiology. Endocrinology and Metabolism·Craig P HasiloGraham F Wagner
Nov 17, 2005·Molecular and Cellular Biology·Andy C-M ChangRoger R Reddel

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Citations

Jul 14, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Richard N Re, Julia L Cook
Jul 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Richard N Re, Julia L Cook
May 11, 2012·Journal of Clinical Biochemistry and Nutrition·Nguyen Trong HungEiji Takeda
Jan 17, 2015·Molecular and Cellular Endocrinology·Silvia R TerraVanessa Schein
Jun 15, 2010·Molecular and Cellular Endocrinology·Jeffrey TurnerGraham F Wagner
Jun 7, 2008·Brain Research·Srdjana RatkovicJohn Ciriello
Jun 16, 2009·General and Comparative Endocrinology·Christopher A LoretzYoshio Takei
Jul 19, 2015·Molecular and Cellular Endocrinology·Vanessa ScheinRoselis S M da Silva
Nov 26, 2011·Molecular and Cellular Endocrinology·B H Y YeungChris K C Wong
Jul 30, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Arezoo MohammadipoorThomas J Bartosh
Apr 6, 2018·International Journal of Molecular Sciences·Lletta Lewis, Raymond W M Kwong
Apr 5, 2014·Journal of the American Society of Nephrology : JASN·Luping HuangDavid Sheikh-Hamad
May 30, 2020·Journal of Cellular and Molecular Medicine·Fangyu ZhaoYupei Zhao
Oct 5, 2020·Molecular Neurobiology·Yewon JeonYongcheol Cho
Aug 31, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jason M MoreauJohn Ciriello

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