Abstract
STC1, a mammalian homologue of stanniocalcin (STC) which plays a major role in calcium/phosphate homeostasis in fish, has been recently isolated. We have characterized the spatiotemporal distribution of STC1 mRNA and protein during mouse embryonic development generally and osteogenesis specifically. Northern blotting analysis of whole embryos showed that STC1 mRNA is highly and differentially expressed during embryogenesis. By in situ hybridization, STC1 mRNA was detected early in mesenchymal condensations and was then found to be highly expressed in perichondrial cells, periosteal cells, and then osteoblasts during endochondral bone formation. In bones forming by intramembranous ossification, STC1 mRNA was not detected until osteogenic cells appeared. The cellular distribution of STC1 protein closely corresponded to that of its mRNA, but the protein was also detected in hypertrophic chondrocytes. In the MC3T3-E1 osteogenic cell model, STC1 protein and mRNA were detectable throughout proliferation and differentiation stages but levels were relatively higher late during nodule formation/mineralization phases. For comparison, STC1 mRNA was also found in epithelial cells of both embryonic and adult intestine that had not previousl...Continue Reading
References
Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R T Franceschi, B S Iyer
Jun 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L D QuarlesR J Wenstrup
Jan 1, 1992·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·K SundellH Kawauchi
Apr 1, 1992·Cell and Tissue Research·T KanekoT Hirano
Aug 11, 1995·Molecular and Cellular Endocrinology·A C ChangR R Reddel
Jan 1, 1993·Molecular and Cellular Endocrinology·T SterbaH G Friesen
May 1, 1996·Endocrinology·M HaddadG F Wagner
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·H S OlsenG F Wagner
Oct 1, 1996·Bone·B SommerA Wetterwald
Nov 29, 1996·Molecular and Cellular Endocrinology·A C ChangR R Reddel
Feb 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G F WagnerJ L Renfro
May 16, 1998·Protein Expression and Purification·J ZhangR Gentz
May 30, 1998·Molecular and Cellular Endocrinology·P De NiuG F Wagner
Aug 4, 1998·The American Journal of Physiology·J C HedgesW T Gerthoffer
Sep 2, 1998·Molecular and Cellular Endocrinology·Y Yoshiko, N Maeda
Sep 2, 1998·Molecular and Cellular Endocrinology·A C Chang, R R Reddel
Oct 1, 1998·Biochemical and Biophysical Research Communications·K IshibashiM Imai
Oct 15, 1998·The Journal of Endocrinology·C K WongG F Wagner
Oct 30, 1998·Endocrinology·R VargheseG E DiMattia
Jan 23, 1999·Bone·G PalmerJ Caverzasio
Feb 18, 1999·Molecular and Cellular Endocrinology·G E DiMattiaG F Wagner
Mar 31, 1999·Endocrinology·Y YoshikoN Maeda
Aug 18, 1999·Electrophoresis·R A WorthingtonJ A Barden
May 16, 2000·The Journal of Endocrinology·W Q JiangR R Reddel
Jun 16, 2000·Molecular and Cellular Endocrinology·P De NiuG F Wagner
Jan 9, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S E Stasko, G F Wagner
Citations
Feb 23, 2010·Transgenic Research·Jennifer JohnstonGabriel E Dimattia
Mar 16, 2011·Genome Biology and Evolution·Graeme J Roch, Nancy M Sherwood
May 17, 2012·Transplantation·Sangho LeeMinnie Sarwal
Nov 17, 2005·Molecular and Cellular Biology·Andy C-M ChangRoger R Reddel
Jul 16, 2009·Journal of Leukocyte Biology·Yanlin WangDavid Sheikh-Hamad
Oct 25, 2012·PloS One·Marcus OlbrichDorothea Alexander
Jan 17, 2015·Molecular and Cellular Endocrinology·Silvia R TerraVanessa Schein
Mar 28, 2008·Archives of Oral Biology·Lokesh SuriEleni Gagari
Dec 22, 2007·Experimental Eye Research·José C RiveraCarmen Clapp
Oct 13, 2004·Peptides·Yuji Yoshiko, Jane E Aubin
Feb 28, 2009·The American Journal of Pathology·Luping HuangDavid Sheikh-Hamad
Nov 26, 2011·Molecular and Cellular Endocrinology·B H Y YeungChris K C Wong
Jul 16, 2016·International Journal of Molecular Sciences·Dajun LiuYing Liu
Mar 23, 2017·Endocrinology·Chia-Hao LinPung-Pung Hwang
Oct 13, 2006·American Journal of Physiology. Renal Physiology·Arup ChakrabortyDavid Sheikh-Hamad
Dec 7, 2017·Oncotarget·Jie-Lin ChenDaping Wang
May 14, 2020·Renal Failure·Shumin BaoWenhu Liu
Feb 9, 2008·Endocrinology·Andy C-M ChangRoger R Reddel
Dec 27, 2005·The Journal of Biological Chemistry·Shufang WuFrancesco De Luca
Sep 29, 2020·Frontiers in Physiology·Lieming YangDegang Liang
Jan 27, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Zhiwen LiuLiyu He
Apr 16, 2020·Bioelectricity·Sarah SundelacruzDavid L Kaplan
Mar 18, 2020·Science Advances·Sébastien SartCharles N Baroud
Dec 10, 2014·Journal of Cardiovascular Pharmacology·Xin ShiYan Qin
Sep 17, 2020·Acta Pharmacologica Sinica·Yin-Bo NiuQi-Bing Mei