PMID: 11897801Mar 19, 2002Paper

Stanniocalcin 1 (STC1) protein and mRNA are developmentally regulated during embryonic mouse osteogenesis: the potential of stc1 as an autocrine/paracrine factor for osteoblast development and bone formation

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Yuji YoshikoNorihiko Maeda

Abstract

STC1, a mammalian homologue of stanniocalcin (STC) which plays a major role in calcium/phosphate homeostasis in fish, has been recently isolated. We have characterized the spatiotemporal distribution of STC1 mRNA and protein during mouse embryonic development generally and osteogenesis specifically. Northern blotting analysis of whole embryos showed that STC1 mRNA is highly and differentially expressed during embryogenesis. By in situ hybridization, STC1 mRNA was detected early in mesenchymal condensations and was then found to be highly expressed in perichondrial cells, periosteal cells, and then osteoblasts during endochondral bone formation. In bones forming by intramembranous ossification, STC1 mRNA was not detected until osteogenic cells appeared. The cellular distribution of STC1 protein closely corresponded to that of its mRNA, but the protein was also detected in hypertrophic chondrocytes. In the MC3T3-E1 osteogenic cell model, STC1 protein and mRNA were detectable throughout proliferation and differentiation stages but levels were relatively higher late during nodule formation/mineralization phases. For comparison, STC1 mRNA was also found in epithelial cells of both embryonic and adult intestine that had not previousl...Continue Reading

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Citations

Mar 16, 2011·Genome Biology and Evolution·Graeme J Roch, Nancy M Sherwood
Nov 17, 2005·Molecular and Cellular Biology·Andy C-M ChangRoger R Reddel
Jul 16, 2009·Journal of Leukocyte Biology·Yanlin WangDavid Sheikh-Hamad
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Feb 9, 2008·Endocrinology·Andy C-M ChangRoger R Reddel
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Jan 27, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Zhiwen LiuLiyu He
Mar 18, 2020·Science Advances·Sébastien SartCharles N Baroud

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