Stanniocalcin from an ancient teleost: a monomeric form of the hormone and a possible extracorpuscular distribution

Molecular and Cellular Endocrinology
Yutaka AmemiyaJohn H Youson

Abstract

Stanniocalcin (STC) is a homodimeric glycoprotein hormone implicated in calcium and phosphate regulation in both teleost fish and mammals. In the present study, immunostaining with salmon STC antiserum demonstrated that STC cells were localized in both the corpuscles of Stannius (CS) and in specific cells of the distal renal tubules of the silver arawana, Osteoglossum bicirrhosum, an ancient ray-finned fish (actinoptergian) and basal teleost (Order Osteoglossiforme). The morphology of these STC-immunoreactive kidney cells was similar to renal 'chloride' (mitochondrial-rich) cells. The immunoreactive renal cells were present in two of three other osteoglossiformes and absent in the gar, a nonteleost actinopterygian and the eel, another basal teleost. The arawana STC cDNA encodes a prehormone of 249 amino acids (aa) with a signal peptide of 31 aa and a mature protein of 218 aa. The deduced aa sequence of arawana STC shows 54-66% identity with other teleost STCs and 51-52% identity with mammalian STC-1. The deduced aa sequence of arawana STC contains ten cysteines, compared with 11 in teleost STC and in mammalian STC-1. The cysteine substitution occurs at the site of inter-monomeric disulfide linkage. Western blot analysis reveale...Continue Reading

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Citations

Dec 31, 2003·General and Comparative Endocrinology·Yutaka Amemiya, John H Youson
Mar 16, 2011·Genome Biology and Evolution·Graeme J Roch, Nancy M Sherwood
May 12, 2011·Integrative and Comparative Biology·Graeme J Roch, Nancy M Sherwood
Aug 29, 2009·BMC Structural Biology·Daniel M TrindadeJörg Kobarg
Aug 12, 2006·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Graham F Wagner, Gabriel E Dimattia
Aug 24, 2002·Endocrinology·Ellen H FilvaroffDorothy M French
Dec 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Deng-Yu TsengPung-Pung Hwang
Dec 14, 2018·Pflügers Archiv : European journal of physiology·Tiziano Verri, Andreas Werner
Feb 7, 2014·The Journal of Experimental Biology·Sílvia F GregórioJuan Fuentes

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