Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression.

Journal of Lipid Research
F Jeffrey FieldSatya N Mathur

Abstract

Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin. ABCA1, ATP binding cassette G1 (ABCG1), ABCG5, ABCG8, and Niemann-Pick C1-like 1 (NPC1L1) mRNA levels were then estimated in duodenum, jejunum, and ileum. Plasma cholesterol was decreased by 36% and 94% in animals fed stanol esters and cholestyramine/lovastatin, respectively. Cholesterol feeding increased plasma cholesterol by 2.5-fold. Plasma plant sterols were unchanged by stanol ester feeding but became undetectable by feeding cholestyramine/lovastatin. Cholesterol and stanols accumulated in enterocytes of animals fed cholesterol and stanol esters, respectively. ABCG5 and ABCG8 mRNA levels were decreased by stanol esters and cholestyramine/lovastatin. Cholesterol feeding markedly increased ABCA1 and ABCG1 expression and modestly increased ABCG5/ABCG8. NPC1L1 mRNA was not significantly altered by any of the diets. ABCG1, ABCG5, ABCG8, and NPC1L1 mRNAs were highest in cells of the upper villus, whereas ABCA1 mRNA was highest in cells of the lower villus. The results suggest that cholesterol lowering effect of stanol esters is unrelated to c...Continue Reading

References

Jul 1, 1976·Atherosclerosis·M SuganoH Morioka
Aug 10, 1983·Biochimica Et Biophysica Acta·I Ikeda, M Sugano
Apr 1, 1982·The American Journal of Clinical Nutrition·F H MattsonJ R Crouse
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·B A JanowskiD J Mangelsdorf
Aug 16, 2001·Trends in Endocrinology and Metabolism : TEM·K LuS B Patel
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Richard E OstlundCurtis A Spilburg
Mar 20, 2002·The Journal of Biological Chemistry·Joyce J RepaDavid J Mangelsdorf
May 23, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Markku NissinenTatu A Miettinen
Jul 2, 2002·Journal of Lipid Research·Shubha MurthyF Jeffrey Field
Jul 10, 2002·The Journal of Biological Chemistry·Torsten PlōschFolkert Kuipers
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jogchum Plat, Ronald P Mensink
Aug 14, 2003·The Journal of Nutritional Biochemistry·Ariënne de JongRonald P Mensink
Feb 21, 2004·Science·Scott W AltmannMichael P Graziano

❮ Previous
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Citations

Jul 11, 2009·Journal of Physiology and Biochemistry·T SanclementeA L García-Otín
Aug 28, 2012·Pharmaceutical Research·Stephen D LeeKishor M Wasan
Mar 30, 2007·Lipids·Richard E Ostlund
Oct 19, 2006·Current Atherosclerosis Reports·Richard E Ostlund, Xiaobo Lin
Aug 12, 2009·Current Atherosclerosis Reports·Laura Calpe-BerdielJoan Carles Escolà-Gil
Jun 9, 2005·Atherosclerosis·Laura Calpe-BerdielFrancisco Blanco-Vaca
Dec 17, 2009·Nutrition Research Reviews·Cesare R SirtoriAnna Arnoldi
May 13, 2011·Journal of Agricultural and Food Chemistry·Jingnan ChenZhen-Yu Chen
Jan 2, 2014·Journal of Agricultural and Food Chemistry·Jingnan ChenZhen-Yu Chen
Aug 23, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mark A ValasekStephen D Turley
Jul 20, 2012·Physiological Reviews·Nada A Abumrad, Nicholas O Davidson
May 11, 2010·PloS One·Christiaan J MassonMaurice M A L Pelsers
Mar 23, 2011·Drug Metabolism and Drug Interactions·Fabiana D V GenvigirRosario D C Hirata
Sep 24, 2011·The American Journal of Clinical Nutrition·Pathmaja ParamsothyRichard E Ostlund
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S Kidambi, S B Patel
Mar 17, 2010·Pharmacology & Therapeutics·Philippe Costet
Feb 6, 2008·Metabolism: Clinical and Experimental·Amira N KassisPeter J H Jones
Jan 16, 2007·Atherosclerosis·Laura Calpe-BerdielFrancisco Blanco-Vaca
Nov 25, 2006·Atherosclerosis·Amira N KassisPeter J H Jones
May 4, 2005·Cardiovascular Drug Reviews·Maria Luz Fernandez, Sonia Vega-López
Jul 3, 2013·Molecular Nutrition & Food Research·Jennifer T SmilowitzJ Bruce German
Apr 26, 2016·Journal of Nutritional Science·Haiqiu HuangThomas T Y Wang
Jun 10, 2015·Critical Reviews in Food Science and Nutrition·Fatemeh Ramezani KapourchaliMohammed H Moghadasian
Jul 6, 2014·Biochimica Et Biophysica Acta·Harumi Uto-KondoKatsunori Ikewaki
Aug 12, 2008·Atherosclerosis·Laura Calpe-BerdielFrancisco Blanco-Vaca
Sep 10, 2005·Journal of Lipid Research·Jogchum PlatRonald P Mensink
Sep 24, 2015·Nutrients·Helena Gylling, Piia Simonen

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