PMID: 5919441Nov 11, 1966

Staphylococcal alpha-toxin: effects on artificial lipid spherules

Science
G WeissmannA W Bernheimer

Abstract

Staphylococcal alpha-toxin induces the release of previously sequestered anions or glucose from artificial phospholipid spherules, an effect abolished by specific antitoxin. Alphatoxin resembles streptolysin S in releasing anions or glucose from spherules prepared without cholesterol, and can be distinguished from the membrane-active polyene amphotericin B, which preferentially disrupts spherules containing cholesterol. It may affect biological structures by a similiar interaction with membrane phospholipids.

Citations

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Related Concepts

Amphotericin B Colloidal Dispersion
Epicholesterol
Glucose, (beta-D)-Isomer
Ions
Phospholipids
Genus staphylococcus
Streptolysins
Toxin

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