PMID: 8593102Feb 1, 1996Paper

Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin: prototypes of pore-forming bacterial cytolysins

Archives of Microbiology
S BhakdiM Palmer

Abstract

Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin are well-studied prototypes of pore-forming bacterial cytotoxins. Each is produced as a water-soluble single-chain polypeptide that inserts into target membranes to form aqueous transmembrane pores. This review will compare properties of the three toxin prototypes, highlighting the similarities and also the differences in their structure, mode of binding, mechanism of pore formation, and the responses they elicit in target cells. Pore-forming toxins represent the most potent and versatile weapons with which invading microbes damage the host macroorganism.

Citations

Jan 7, 1998·Protein Science : a Publication of the Protein Society·E GouauxL Song
Nov 24, 1999·Archives of Biochemistry and Biophysics·M KuhnW Goebel
Jan 24, 1998·Biochemical and Biophysical Research Communications·G AnderluhP Macek
Feb 16, 2010·The Journal of Membrane Biology·Young-Keun KwakBeatrix Vécsey-Semjén
Mar 27, 2010·The Journal of Membrane Biology·Beatrix Vécsey-SemjénRoland Möllby
Mar 24, 2009·Current Microbiology·Jie LiuRuoyu Yan
Sep 14, 2012·Medical Microbiology and Immunology·Karina Reiss, Sucharit Bhakdi
Mar 31, 2005·Journal of Structural Biology·Thanh X DangElizabeth M Wilson-Kubalek
Feb 13, 1999·European Journal of Pharmacology·H KookY H Baik
Mar 4, 2000·Advanced Drug Delivery Reviews·C J Provoda, K D Lee
Aug 1, 1997·Current Opinion in Structural Biology·E Gouaux
Dec 17, 1998·Trends in Cell Biology·K van Leyen
Aug 14, 2003·Trends in Microbiology·Kartik Chandran, Max L Nibert
Apr 13, 1999·Bioorganic & Medicinal Chemistry·L P Liu, C M Deber
Jun 12, 2003·Methods : a Companion to Methods in Enzymology·Thomas WeimbsGeri Kreitzer
Aug 17, 2002·Protein Expression and Purification·Scott C KachlanyDavid H Figurski
Mar 6, 1999·Current Opinion in Microbiology·P BoquetI Just
Feb 16, 2006·Biochemistry·Marnie L Peterson, Patrick M Schlievert
Jul 4, 2001·Nature Reviews. Molecular Cell Biology·G Schiavo, F G van der Goot
Feb 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marianne SkalsHelle A Praetorius
Oct 1, 2010·Science Translational Medicine·Rasmus LarsenMiguel P Soares
Feb 13, 2001·Infection and Immunity·S J VesperR A Haugland
Mar 16, 2002·Infection and Immunity·Stephen J Vesper, Mary Jo Vesper
Nov 28, 2007·Journal of Bacteriology·Michelle CiszArne Rietsch
Sep 2, 2003·Journal of Bacteriology·Sun Nyunt WaiBernt Eric Uhlin
Feb 24, 2006·Journal of Molecular Microbiology and Biotechnology·Hisashi KimotoAkira Taketo
Feb 6, 2002·Bioscience, Biotechnology, and Biochemistry·I YamamotoA Taketo

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