Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glucocorticoid-induced TNF receptor-related protein ligand on monocytes

The Journal of Allergy and Clinical Immunology
Ivan D CardonaDonald Y M Leung

Abstract

Superantigens inhibit naturally occurring CD4+CD25+ regulatory T-cell (nTreg) activity, yet the mechanism for this is unknown. We tested the hypothesis that staphylococcal enterotoxin B (SEB), a prototypic superantigen, inhibits the ability of nTregs to suppress T-effector cell (Teff) proliferation by an antigen-presenting cell-dependent cell contact mechanism and the induction of glucocorticoid-induced TNF receptor-related protein ligand (GITR-L) on monocytes. Cell proliferation assays were performed on immunomagnetic-bead separated CD4+CD25+, CD4+CD25- T cells and CD14+ monocytes using anti-CD3, SEB, or a neutralizing anti-GITR-L antibody for stimulation. A cytokine permeable membrane insert separating cells in culture was used to evaluate the role of cell contact. Proliferation was measured by [3H]-thymidine incorporation or a carboxyfluorescein diacetate succinimidyl ester assay. GITR-L expression was determined by RT-PCR and immunostaining. Antigen-presenting cell contact was required for proliferation of nTregs and loss of their ability to suppress Teff proliferation as confirmed by carboxyfluorescein diacetate succinimidyl ester. At baseline, monocytes expressed no GITR-L, but after SEB stimulation, GITR-L gene and prote...Continue Reading

References

Apr 11, 2000·The Journal of Allergy and Clinical Immunology·P J HaukD Y Leung
Jan 18, 2003·Science·Chandrashekhar Pasare, Ruslan Medzhitov
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Aug 22, 2003·Clinical and Experimental Immunology·T Proft, J D Fraser
Nov 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Masahide ToneHerman Waldmann
Mar 24, 2004·Seminars in Immunology·Clare Baecher-AllanDavid A Hafler
Apr 7, 2004·The Journal of Experimental Medicine·Vissia VigliettaDavid A Hafler
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Liang-Shiou OuDonald Y M Leung
May 1, 2004·The Journal of Experimental Medicine·Martin A KriegelHanns-Martin Lorenz
Aug 19, 2004·The Journal of Allergy and Clinical Immunology·Javier Chinen, William T Shearer
Aug 25, 2004·Investigative Ophthalmology & Visual Science·Ben J KimRobert B Nussenblatt
Sep 7, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H GrindebackeA Rudin
Nov 3, 2004·The Journal of Clinical Investigation·Zoltán Fehérvari, Shimon Sakaguchi
Jul 2, 2005·The Journal of Allergy and Clinical Immunology·Scott H Sicherer, Donald Y M Leung
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Talal A Chatila
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Christine M Seroogy, James E Gern
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Elena GolevaDonald Y M Leung

❮ Previous
Next ❯

Citations

Apr 10, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Chia-Chuan WuJaw-Ji Tsai
Apr 4, 2008·The New England Journal of Medicine·Thomas Bieber
Feb 2, 2011·Infection and Immunity·Ranjani PrabhakaraMark E Shirtliff
Jul 16, 2010·Journal of Leukocyte Biology·Dan Ilkovitch
Feb 4, 2014·Cytokine & Growth Factor Reviews·Derek L Clouthier, Tania H Watts
Nov 16, 2013·The Journal of Allergy and Clinical Immunology. in Practice·Marcel M BergmannPhilippe A Eigenmann
Jun 29, 2012·The Journal of Allergy and Clinical Immunology·Claus BachertPeter Howarth
Sep 3, 2010·The Journal of Allergy and Clinical Immunology·Claus BachertKristel Van Steen
Nov 22, 2008·The Journal of Allergy and Clinical Immunology·Kirthana GaneshanPaul J Bryce
Jan 8, 2008·The Journal of Allergy and Clinical Immunology·Amanda J ReeferJudith A Woodfolk
May 18, 2007·The Journal of Allergy and Clinical Immunology·Amanda J ReeferJudith A Woodfolk
Feb 13, 2007·The Journal of Allergy and Clinical Immunology·Aida Semic-JusufagicAdnan Custovic
Oct 31, 2006·Journal of Reproductive Immunology·Govindarajan RajagopalanChella S David
Jun 23, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P J Barnes
Mar 6, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G XuH B Li
Aug 2, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Eckard HamelmannMagnus Wickman
Dec 2, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Ogg
Jun 21, 2011·Immunological Reviews·Mark Boguniewicz, Donald Y M Leung
Jun 21, 2011·Immunological Reviews·Peter J Barnes
Oct 28, 2011·British Journal of Pharmacology·Giuseppe NocentiniCarlo Riccardi
Jun 13, 2012·Scandinavian Journal of Immunology·A LesiakJ Narbutt
Nov 13, 2010·Clinical and Experimental Dermatology·P L R GomesG S Ogg
Aug 13, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C A Pérez NovoC Bachert
Jun 26, 2007·The Journal of Allergy and Clinical Immunology·Javier Chinen, William T Shearer
Jan 30, 2010·The Journal of Allergy and Clinical Immunology·Mark Boguniewicz, Donald Y M Leung
Oct 6, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Woo-Jung SongSang-Heon Cho
Jan 12, 2008·Current Opinion in Allergy and Clinical Immunology·Claus BachertPhilippe Gevaert
Jun 16, 2010·Annals of Dermatology·Thomas Bieber
Nov 9, 2007·Current Opinion in Allergy and Clinical Immunology·Natalija Novak
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sebastian KerzelMichael Zemlin
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony JoethamErwin W Gelfand
Jul 30, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony JoethamErwin W Gelfand

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.