Staphylococcal enterotoxin C2 promotes osteogenesis and suppresses osteoclastogenesis of human mesenchymal stem cells

Experimental Cell Research
Wei-ming FuHsiang-fu Kung

Abstract

As a super-antigen, staphylococcal enterotoxin C2 (SEC2) stimulates the release of massive inflammatory cytokines such as interferon-gamma (IFN-γ), interleukin-1 (IL-1) and interleukin-2 (IL-2) which are documented to implicate osteoblast differentiation. In the present study, SEC2 was found to significantly improve the osteoblast differentiation by up-regulating BMP2 and Runx2/Cbfa1 expression. Interferon (IFN)-inducible gene IFI16, a co-activator of Runx2/Cbfa1, was also activated by SEC2 in the osteoblast differentiation. In addition, exogenous introduction of SEC2 stimulated OPG expression and suppressed RANKL, suggesting suppression of osteoclastogenesis in hMSCs. Therefore, our results displayed that SEC2 plays an important role in the commitment of MSC to the osteoblast and it might be a potential new therapeutic candidate for bone regeneration.

References

Dec 30, 1992·Biochemical and Biophysical Research Communications·K UenoY Koshihara
Jan 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·L RinkH Kirchner
Feb 1, 1997·Journal of Cellular Biochemistry·N JaiswalS P Bruder
Apr 2, 1999·Science·M F PittengerD R Marshak
Apr 10, 2002·Molecular and Cellular Biology·Chuan-ju LiuPeter Lengyel
Oct 24, 2003·Cancer Immunology, Immunotherapy : CII·Wenxue MaHongchuan Jin
Feb 8, 2005·Biochemical and Biophysical Research Communications·Manhui PangBruce R Troen
Aug 5, 2005·Applied Microbiology and Biotechnology·Xu Ming-Kai, Zhang Cheng-Gang
Aug 16, 2008·The Journal of Biological Chemistry·Takuma MatsubaraToshiyuki Yoneda
Sep 27, 2008·Cancer Immunology, Immunotherapy : CII·Xiaogang WangChenggang Zhang
Apr 28, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jin-Fang ZhangHsiang-Fu Kung
Mar 2, 2011·Arthritis and Rheumatism·Koichi OshitaYoshiya Tanaka
Aug 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jin-fang ZhangHsiang-fu Kung
May 24, 2012·Biochemical and Biophysical Research Communications·Václav BrázdaCheryl H Arrowsmith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.