PMID: 11897995Mar 19, 2002Paper

Staphylococcal exotoxins exert proinflammatory effects through inhibition of eosinophil apoptosis, increased surface antigen expression (CD11b, CD45, CD54, and CD69), and enhanced cytokine-activated oxidative burst, thereby triggering allergic inflammatory reactions

The Journal of Allergy and Clinical Immunology
Bettina WediA Kapp

Abstract

Staphylococcus aureus colonization of the skin represents a potent trigger factor of atopic dermatitis. Our previous studies demonstrated that in atopic dermatitis eosinophil apoptosis is significantly delayed. We sought to investigate the effect of staphylococcal exotoxins (SETs) on eosinophil apoptosis and functional activities. Apoptotic eosinophils were investigated by determining their hypodiploid DNA peak. Eosinophil surface-antigen expression and intracellular production of hydrogen peroxide were assessed by means of flow cytometric analysis and respiratory burst by lucigenin-dependent chemiluminescence. The SETs SEA, SEB, SEC, and toxic shock syndrome toxin 1 significantly inhibited eosinophil apoptosis in a manner comparable with that of high concentrations of IL-3. The LPS inhibitor polymyxin B was found to significantly inhibit LPS-mediated, but not SET-mediated, inhibition of apoptosis. Neither SETs nor LPS was able to modulate eosinophil surface expression of CD9, CD11a, CD16, CD40, CD44, or CD63. However, 24- and 48-hour incubation with all SETs, but not with LPS, significantly upregulated expression of CD11b and CD45 in a manner similar to that of IL-3, whereas dexamethasone induced a downregulation. Moreover, al...Continue Reading

Citations

Sep 27, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y Minai-FlemingerF Levi-Schaffer
Jun 1, 2006·American Journal of Clinical Dermatology·Babu M Medi, Jagdish Singh
Dec 2, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ahmet KaraHalil Elden
Oct 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y DulkysJ Elsner
May 19, 2012·Journal of Leukocyte Biology·Koa HosokiTakao Fujisawa
Jun 15, 2019·Toxins·Fabio Seiti Yamada YoshikawaRaquel Leao Orfali
Jan 25, 2003·Critical Care Medicine·John A Kellum
Mar 18, 2006·Clinical and Experimental Immunology·Barbara S Baker
Jun 21, 2019·Current Allergy and Asthma Reports·Kim S LeMessurier, Amali E Samarasinghe
Oct 20, 2011·Orthopaedic Surgery·Ren-de NingXiao-kui Guo
Jul 14, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·T de Oliveira TitzV Aoki
Feb 3, 2016·Allergy·Roopesh Singh Gangwar, Francesca Levi-Schaffer
Jan 4, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Eun Jung LeeDong-Joon Park
Jul 16, 2019·Respiratory Medicine·Martina FloraCecilia Calabrese
Oct 9, 2007·Advances in Pediatrics·Alexander K C LeungWm Lane M Robson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.