PMID: 3772046Nov 1, 1986Paper

Staphylococcal infections in aging mice

Journal of Gerontology
D B LouriaM Kaplan

Abstract

Aging (17 to 22 months old) and young (1 1/2 to 2 months old) mice were infected with 5 X 10(7) staphylococci. Twenty-eight-day mortality was 70% in senescent mice and 14.3% in young mice. Phagocytosis and intracellular killing of staphylococci by polymorphonuclear leukocytes and mononuclear cells and leukocyte mobilization were studied after intraperitoneal infection. Intracellular killing by polymorphonuclear leukocytes was slightly more effective in young mice but older mice mobilized about twice as many polymorphonuclear leukocytes in a 4-hour period. In older mice the lethality of intraperitoneally-administered staphylococcal toxins and salmonella endotoxin was markedly increased, the mortality rates in old and young mice being virtually identical to those found after intravenous infection with living staphylococci.

Citations

Nov 1, 1992·Mechanisms of Ageing and Development·M J Steffen, J L Ebersole
Jun 1, 1994·Immunology Letters·J W Albright, J F Albright
Jan 1, 1990·Experimental Gerontology·S F Bradley, C A Kauffman
Oct 1, 1988·Medical Hypotheses·G BounousP Gold
Jan 6, 2000·The Journal of Experimental Medicine·C A ThomasJ El Khoury

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