PMID: 1194714Dec 1, 1975Paper

Staphylococcal toxic epidermal necrolysis: pathogenesis and studies on the subcellular site of action of exfoliatin

The Journal of Investigative Dermatology
P EliasK Wolff

Abstract

An exfoliating substance elaborated by certain phage Group 2 staphylococci causes toxic epidermal necrolysis. Both in man and in the newborn mouse, intraepidermal cleavage is the predominant histologic feature following exposure to this toxin. Electron microscopic study of sequential biopsy specimens obtained from neonatal mice and from organ cultures of human skin revealed intercellular cleavage and cell separation. The extracellular nature of the exfoliative process was confirmed in several ways: (1) perfused tracers did not penetrate cells during cell separation; (2) cultured cells exposed to high doses of exfoliating fractions demonstrated no signs of injury; and (3) cleaved surfaces examined by scanning electron microscopy and surface replication demonstrated intact plasma membranes. When fractions capable of inducing exfoliation were applied to cultured keratinocytes of fibroblasts, sperm, or lymphocyte suspensions, and to human or mouse skin in vivo, they did not alter the distribution or intensity of concanavalin A binding, ruthenium red staining, pemphigus antibody binding, or HL-A surface antigens. Therefore, while the pathogenesis of staphylococcal toxic epidermal necrolysis involves intercellular cleavage, the molec...Continue Reading

Citations

May 4, 1979·Archives of Dermatological Research·P O FritschP M Elias
Mar 1, 1987·European Journal of Pediatrics·T SluysmansG Cornu
Sep 1, 1990·The Journal of Dermatology·E GentilhommeJ Thivolet
Jan 1, 1981·Archives of Dermatological Research·P M Elias
Jan 1, 1980·The British Journal of Dermatology·C J Skerrow
Sep 1, 1976·The British Journal of Dermatology·P FritschJ Varga
Feb 1, 1981·The Journal of Dermatology·K NishiokaS Sano
May 1, 1993·The British Journal of Dermatology·E ProkschK R Feingold
Jan 1, 1981·International Journal of Dermatology·P M Elias
Mar 1, 1987·The Histochemical Journal·T P SmithC J Bailey
May 1, 1977·The British Journal of Dermatology·R L DimondO Braun-Falco
Jan 1, 1996·Journal of Pharmaceutical Sciences·T OgisoM Iwaki
Feb 13, 2003·Journal of the American Academy of Dermatology·Masayuki Amagai
Sep 1, 1979·Microbiological Reviews·M Rogolsky
Nov 1, 1979·The Journal of Investigative Dermatology·P M EliasR J White
Dec 1, 1977·The Journal of Investigative Dermatology·P M EliasD S Friend
May 14, 2004·The Journal of Investigative Dermatology·Lisa R W Plano
Jan 1, 1982·The Journal of Infection·C G Gemmell
Jan 1, 1994·Pathology, Research and Practice·R HoffmannJ Leititis

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