Staphylococci evade the innate immune response by disarming neutrophils and forming biofilms.

FEBS Letters
Lisanne de VorJos A G van Strijp

Abstract

Staphylococcus aureus and Staphylococcus epidermidis can cause many types of infections, ranging from skin infections to implant-associated infections. The primary innate immune response against bacterial infections involves complement activation, recruitment of phagocytes (most importantly neutrophils), and subsequent killing of the pathogen. However, staphylococci are not innocent bystanders; they actively obstruct this immune attack. To do that, S. aureus secretes several immune-evasion proteins to resist attack by the innate immune system. Furthermore, S. aureus and S. epidermidis are known for their ability to form biofilms on implanted medical devices and host tissues, which provides another important immune-evasion mechanism. Understanding these different strategies to resist immune attack will help to develop novel therapies against staphylococcal infections.

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Citations

Aug 25, 2020·FEBS Letters·Seppo Meri, Hanna Jarva
Jun 25, 2020·Current Drug Targets·Hongmin SunDavid W Anderson
Dec 29, 2020·Clinical Microbiology Reviews·Simon Heilbronner, Timothy J Foster
Mar 13, 2021·Frontiers in Immunology·Sharon Db de MoraisTammy Kielian
Apr 20, 2021·Enfermedades infecciosas y microbiología clínica·Beatriz AlonsoMaría Guembe
Jun 3, 2021·Antibiotics·Denis SwolanaRobert D Wojtyczka
Aug 8, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Germana LentiniConcetta Beninati

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