PMID: 9181833Mar 1, 1997Paper

Staphylococcus-associated blepharokeratoconjunctivitis. Clinical findings, pathogenesis and therapy

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
M R TetzH E Völcker

Abstract

Staphylococci represent an important source of external infections of the eye. In addition to acute staphylococcal conjunctivitis a spectrum of subacute or chronic disease may be found. According to Valenton und Okumoto, with this staphylococci-associated blepharo-kerato-conjunctivitis in culture-positive cases S. aureus is found in 31% and S. epidermidis in 69% of smears. Microbiallergic and toxic mechanisms are the underlying etiology. We report on a series of 38 patients with "red eye" that were seen between 1992 and 1994 in the external disease clinic at the Department of Ophthalmology, University of Heidelberg. There were 17 female and 21 male patients. The mean age was 53 +/- 20 years. The patient's complaints included recurrent red eyes with discomfort and pain. Clinically, a squamous blepharitis (63%) and conjunctivitis (87%) were present. Upon biomicroscopic evaluation, a corneal involvement could be found in 80% of cases. In 66% of cases conjunctival swabs were positive for staphylococci. The blepharitis may be squamous or ulcerative. The underlying cause is a dermal irritation by staphylococcal toxins. As early as 1937, Thygeson and Allan postulated a toxin-induced skin irritation by a "dermonecrotic factor." In chro...Continue Reading

Citations

Apr 7, 2007·Cornea·Tsung-Jen WangYu-Chih Hou
Jul 31, 2010·Immunology and Allergy Clinics of North America·Brett Bielory, Leonard Bielory

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