Staphylococcus aureus bacteremia in solid organ transplant recipients: evidence for improved survival when compared with nontransplant patients

Transplantation
Maricar F MalinisDavid van Duin

Abstract

Staphylococcus aureus bacteremia (SAB) is an important cause of morbidity and mortality. Herein, we describe the incidence, clinical characteristics, and outcomes of SAB after solid organ transplantation (SOT) and compare these features with non-SOT controls. In a single-center retrospective study, blood cultures positive for S. aureus were obtained from January 1, 2000, to December 31, 2008. Chart review was performed on all SOT recipients with SAB. The social security death index was used to determine all-cause mortality. Seventy of 2959 patients with SAB were SOT recipients (26 lung, 19 liver, 18 kidney, and seven heart). The overall attack rate of SAB in SOT was 22.9/1000 transplant patients. Early-onset SAB (≤ 90 days) was more frequent in liver recipients (79%), when compared with kidney recipients (17%). All-cause 30-day and 1-year mortality rates were 6% and 28% in SOT, respectively. Pneumonia as a source was associated with an increased 30-day mortality (18% vs. 2%, P = 0.04). Comparing SOT versus non-SOT controls, methicillin resistance was more frequent (86% vs. 52%, P < 0.0001), and duration of bacteremia was longer (mean 3.8 vs. 1.6 days, P < 0.01). SOT status was independently associated with lower risk of 30-day ...Continue Reading

References

Jan 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M PujolF Gudiol
Apr 29, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·A J MangramW R Jarvis
Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N SinghI R Marino
Jun 20, 2002·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J Torre-CisnerosM A Gómez-Bravo
Sep 27, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Thomas P LodiseMichael Rybak
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Feb 16, 2006·Transplantation·Claudia RodríguezEmilio Bouza
Feb 13, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S HusainN Singh
Sep 26, 2007·Archives of Internal Medicine·Claudia HawkinsMaureen Bolon
Oct 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gary A NoskinMurtuza Bharmal
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy C JenkinsWilliam J Burman
Jun 19, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D L RussellD A Pegues
May 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B HamandiL Thabane
Jul 23, 2009·Current Opinion in Organ Transplantation·Jeffrey Hafkin, Emily Blumberg
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Oriol ManuelDeepali Kumar
Oct 27, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·François HaddadJose G Montoya
May 25, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H AsgeirssonM Kristjansson
May 25, 2010·The American Journal of Medicine·Hitoshi HondaDavid K Warren
Sep 9, 2011·Current Opinion in Critical Care·W Joost Wiersinga

❮ Previous
Next ❯

Citations

May 31, 2014·World Journal of Gastroenterology : WJG·Guilherme Santoro-Lopes, Erika Ferraz de Gouvêa
May 31, 2014·World Journal of Gastroenterology : WJG·Sang Il Kim
Nov 26, 2014·Transplantation Proceedings·E DaskalakiS Drakopoulos
Oct 23, 2015·Diabetes Research and Clinical Practice·J M de Miguel-YanesA López-de-Andrés
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C GarzoniUNKNOWN AST Infectious Diseases Community of Practice
Feb 17, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A L GregsonJ A Belperio
May 6, 2015·Current Infectious Disease Reports·Andre C Kalil, Steven M Opal
Jan 24, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Thomas SchachtnerPetra Reinke
May 29, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Michele BartolettiMaddalena Giannella
Jul 22, 2020·The Journal of Infectious Diseases·Randy J McCreeryAndre C Kalil
May 25, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John P DonnellyHenry E Wang
Mar 10, 2021·European Journal of Internal Medicine·Manuel Martínez-SellésUNKNOWN Spanish Collaboration on Endocarditis—Grupo de Apoyo al Manejo de la Endocarditis infecciosa en ESpaña (GAMES)
Nov 2, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Emily M EichenbergerStacey A Maskarinec
May 31, 2019·Current Opinion in Organ Transplantation·Jonathan Hand, Gopi Patel
Sep 10, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Emily M EichenbergerVance G Fowler

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
J J WadeR Williams
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Frédéric BertBruno Fantin
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
J Torre-CisnerosM A Gómez-Bravo
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Sang-Oh LeeRaymund R Razonable
© 2022 Meta ULC. All rights reserved