Staphylococcus aureus carriage rates and antibiotic resistance patterns in patients with acne vulgaris

Journal of the American Academy of Dermatology
Gregory R DelostJenifer Lloyd

Abstract

Overuse of antibiotics has led to the development of antibiotic-resistant strains of Staphylococcus aureus, which are occurring more frequently within the community. We sought to determine whether long-term antibiotic therapy for acne alter the carriage rate and antibiotic resistance profiles of S aureus. This was a prospective, cross-sectional, quasiexperimental study. Samples of anterior nares were obtained from dermatology patients given a diagnosis of acne vulgaris (n = 263) who were treated with antibiotics (n = 142) or who were not treated with antibiotics (n = 121). Specimens were tested for the presence of S aureus by growth on mannitol salt agar and then isolated on 5% sheep blood agar. Identification was confirmed based on colonial morphology, Gram stain, catalase, and coagulase testing. Antibiotic susceptibility testing was performed using the VITEK 2 system (bioMerieux, Marcy-l'Étoile, France). The S aureus carriage rate was significantly lower in patients with acne treated with antibiotics (6.3%) compared with those not treated with antibiotics (15.7%; P = .016). The percentage of S aureus isolates resistant to 1 or more antibiotics did not significantly differ between the 2 groups (P = .434). Cross-sectional study...Continue Reading

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Citations

Feb 23, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·E E RobertsD A Wetter
Oct 4, 2020·Pediatric Dermatology·Erin E RobertsDavid A Wetter
Jun 20, 2017·Expert Opinion on Investigational Drugs·Christos C ZouboulisHarald P M Gollnick

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