Abstract
Overuse of antibiotics has led to the development of antibiotic-resistant strains of Staphylococcus aureus, which are occurring more frequently within the community. We sought to determine whether long-term antibiotic therapy for acne alter the carriage rate and antibiotic resistance profiles of S aureus. This was a prospective, cross-sectional, quasiexperimental study. Samples of anterior nares were obtained from dermatology patients given a diagnosis of acne vulgaris (n = 263) who were treated with antibiotics (n = 142) or who were not treated with antibiotics (n = 121). Specimens were tested for the presence of S aureus by growth on mannitol salt agar and then isolated on 5% sheep blood agar. Identification was confirmed based on colonial morphology, Gram stain, catalase, and coagulase testing. Antibiotic susceptibility testing was performed using the VITEK 2 system (bioMerieux, Marcy-l'Étoile, France). The S aureus carriage rate was significantly lower in patients with acne treated with antibiotics (6.3%) compared with those not treated with antibiotics (15.7%; P = .016). The percentage of S aureus isolates resistant to 1 or more antibiotics did not significantly differ between the 2 groups (P = .434). Cross-sectional study...Continue Reading
References
Feb 15, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·J J Leyden
Jan 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James S Lewis, James H Jorgensen
May 27, 2005·Antimicrobial Agents and Chemotherapy·Susana Chavez-BuenoPeter C Appelbaum
Dec 20, 2005·The Journal of Infectious Diseases·Matthew J KuehnertFred C Tenover
Mar 30, 2006·Annals of Family Medicine·Arch G MainousVanessa A Diaz
Oct 18, 2007·JAMA : the Journal of the American Medical Association·R Monina KlevensUNKNOWN Active Bacterial Core surveillance (ABCs) MRSA Investigators
Nov 28, 2009·Epidemiology and Infection·M A HalablabG F Araj
Aug 10, 2010·Nursing for Women's Health·Janis R Guilbeau, Lisa P Broussard
Nov 28, 2012·North American Journal of Medical Sciences·Farzin KhorvashTahmineh Narimani
Dec 6, 2012·The British Journal of Dermatology·K Bhate, H C Williams
Feb 26, 2013·International Journal of Dermatology·Fabiola SchaferPatricia Garcia
Jun 26, 2014·International Journal of Dermatology·Pınar OzuguzSemsettin Karaca
Mar 21, 2015·JAMA Dermatology·Kathryn L AndersonSteven R Feldman
Citations
Jan 21, 2017·International Journal of Molecular Sciences·Crina SaviucVeronica Lazăr
Feb 23, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·E E RobertsD A Wetter
Oct 4, 2020·Pediatric Dermatology·Erin E RobertsDavid A Wetter
Jun 20, 2017·Expert Opinion on Investigational Drugs·Christos C ZouboulisHarald P M Gollnick