Staphylococcus aureus CC398: host adaptation and emergence of methicillin resistance in livestock.

Lance B PriceFrank M Aarestrup


Since its discovery in the early 2000s, methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 398 (CC398) has become a rapidly emerging cause of human infections, most often associated with livestock exposure. We applied whole-genome sequence typing to characterize a diverse collection of CC398 isolates (n = 89), including MRSA and methicillin-susceptible S. aureus (MSSA) from animals and humans spanning 19 countries and four continents. We identified 4,238 single nucleotide polymorphisms (SNPs) among the 89 core genomes. Minimal homoplasy (consistency index = 0.9591) was detected among parsimony-informative SNPs, allowing for the generation of a highly accurate phylogenetic reconstruction of the CC398 clonal lineage. Phylogenetic analyses revealed that MSSA from humans formed the most ancestral clades. The most derived lineages were composed predominantly of livestock-associated MRSA possessing three different staphylococcal cassette chromosome mec element (SCCmec) types (IV, V, and VII-like) including nine subtypes. The human-associated isolates from the basal clades carried phages encoding human innate immune modulators that were largely missing among the livestock-associated isolates. Our results strongly sugges...Continue Reading


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Aug 3, 2012·Animal Health Research Reviews·Carl J YeomanBryan A White
Jul 12, 2012·The Journal of Antimicrobial Chemotherapy·Ea ZankariMette Voldby Larsen
Sep 11, 2012·Applied and Environmental Microbiology·Anne OppligerOlga Sakwinska
Oct 9, 2012·Applied and Environmental Microbiology·Alex J McCarthyJodi A Lindsay
May 15, 2012·Journal of Bacteriology·Tracy H HazenDavid A Rasko
Nov 1, 2013·Journal of Clinical Microbiology·Henrik HasmanFrank M Aarestrup
Jan 11, 2013·BMC Genomics·Pimlapas LeekitcharoenphonFrank M Aarestrup
Apr 4, 2012·Emerging Infectious Diseases·José R MediavillaBarry N Kreiswirth
Apr 24, 2014·MBio·Fabienne WichmannJo Handelsman

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