Staphylococcus aureus dry stress survivors have a heritable fitness advantage in subsequent dry exposure

Microbes and Infection
Lisa MaudsdotterKazuya Morikawa

Abstract

Staphylococcus aureus is a major cause of hospital-acquired infections. The ability to survive on abiotic surfaces is an important characteristic that facilitates transmission between human hosts. We found that S. aureus survivors of dry surface incubation are resistant to subsequent dry stress exposure. Survivors also had reduced sensitivity to the disinfectant chlorhexidine gluconate, but not to ethanol. By using a set of mutants in cardiolipin synthase genes, we further demonstrated that the housekeeping cardiolipin synthase, Cls2, was significant for survival on dry surface. Taken together, this study provides insights into S. aureus survival outside of a host.

References

Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Jan 18, 2006·Nature Reviews. Microbiology·Steven E Finkel
Aug 24, 2006·Molecular Microbiology·Kouji MatsumotoHiroshi Hara
May 17, 2007·Molecular Microbiology·Tatyana RomantsovJanet M Wood
Feb 26, 2009·FEMS Microbiology Letters·Alison M Kraigsley, Steven E Finkel
Mar 31, 2009·Biochimica Et Biophysica Acta·Ruthven N A H Lewis, Ronald N McElhaney
Jul 20, 2010·Biochimica Et Biophysica Acta·Dimitri TolleterDavid Macherel
Nov 23, 2010·Archives of Microbiology·Plykaeow Chaibenjawong, Simon J Foster
Mar 13, 2014·The Journal of Biological Chemistry·TianHua ZhangEvan Mintzer
May 27, 2014·American Journal of Infection Control·Ilana Livshiz-RivenOfra Anson
Jun 5, 2014·Journal of Travel Medicine·Yvonne P ZhouLi-Yang Hsu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Related Papers

American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses
Deana SievertMargo A Halm
The New England Journal of Medicine
C K Bhatia
© 2022 Meta ULC. All rights reserved