Staphylococcus aureus Fatty Acid Kinase FakA Modulates Pathogenesis during Skin Infection via Proteases.

Infection and Immunity
Miranda J RidderJeffrey L Bose

Abstract

Staphylococcus aureus fatty acid kinase FakA is necessary for the incorporation of exogenous fatty acids into the lipid membrane. We previously demonstrated that the inactivation of fakA leads to decreased α-hemolysin (Hla) production but increased expression of the proteases SspAB and aureolysin in vitro, and that the ΔfakA mutant causes larger lesions than the wild type (WT) during murine skin infection. As expected, necrosis is Hla dependent in the presence or absence of FakA, as both hla and hla ΔfakA mutants are unable to cause necrosis of the skin. At day 4 postinfection, while the ΔfakA mutant maintains larger and more necrotic abscesses, bacterial numbers are similar to those of the WT, indicating the enhanced tissue damage of mice infected with the ΔfakA mutant is not due to an increase in bacterial burden. At this early stage of infection, skin infected with the ΔfakA mutant has decreased levels of proinflammatory cytokines, such as interleukin-17A (IL-17A) and IL-1α, compared to those of WT-infected skin. At a later stage of infection (day 7), abscess resolution and bacterial clearance are hindered in ΔfakA mutant-infected mice. The paradoxical findings of decreased Hla in vitro but increased necrosis in vivo led us ...Continue Reading

References

Aug 1, 1997·The Journal of Infectious Diseases·T van der PollS F Lowry
Nov 4, 2000·The Journal of Biological Chemistry·N InoharaG Nuñez
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J WitowskiA Jörres
Jan 2, 2004·Microbiology·Lindsey ShawSimon J Foster
Jun 19, 2004·The International Journal of Biochemistry & Cell Biology·M Maurer, E von Stebut
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Magdalena Sieprawska-LupaJan Potempa
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah C Mullaly, Paul Kubes
Jul 7, 2007·International Journal of Dermatology·Barbara AufieroGeorge J Murakawa
Feb 9, 2008·Emerging Infectious Diseases·Eili KleinRamanan Laxminarayan
Jun 3, 2009·The Journal of Experimental Medicine·Yoshiyuki MinegishiHajime Karasuyama
Sep 1, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raúl Muñoz-PlanilloGabriel Núñez
Oct 9, 2009·The Journal of Investigative Dermatology·Yusuke HirasawaHideoki Ogawa
Apr 7, 2010·The Journal of Clinical Investigation·John S ChoLloyd S Miller
Dec 15, 2010·Journal of Biomedicine & Biotechnology·Victor W WongGeoffrey C Gurtner
Apr 20, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander J LaarmanSuzan H M Rooijakkers
Jul 26, 2011·Journal of Bacteriology·Mirka E WörmannAngelika Gründling
Aug 19, 2011·The Journal of Infectious Diseases·Scott D KobayashiFrank R Deleo
Nov 15, 2011·Seminars in Immunopathology·Kevin M Rigby, Frank R DeLeo
Sep 11, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dane Parker, Alice Prince
Jul 31, 2013·Toxins·Bryan J Berube, Juliane Bubeck Wardenburg
Feb 20, 2014·Infection and Immunity·Jeffrey L BoseKenneth W Bayles
Mar 10, 2015·The American Journal of Pathology·Scott D KobayashiFrank R DeLeo
Jul 13, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria-Luisa AlegreRobert S Daum
Oct 25, 2016·The Journal of Investigative Dermatology·Bingjie WangDonald J Davidson
Dec 30, 2016·Journal of Bacteriology·Christina N KruteJeffrey L Bose

❮ Previous
Next ❯

Citations

Aug 28, 2021·International Journal of Molecular Sciences·Leszek BlicharzZbigniew Samochocki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.