Staphylococcus aureus infective endocarditis versus bacteremia strains: Subtle genetic differences at stake

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Coralie BouchiatFrench VIRSTA Study Group

Abstract

Infective endocarditis (IE)((1)) is a severe condition complicating 10-25% of Staphylococcus aureus bacteremia. Although host-related IE risk factors have been identified, the involvement of bacterial features in IE complication is still unclear. We characterized strictly defined IE and bacteremia isolates and searched for discriminant features. S. aureus isolates causing community-acquired, definite native-valve IE (n=72) and bacteremia (n=54) were collected prospectively as part of a French multicenter cohort. Phenotypic traits previously reported or hypothesized to be involved in staphylococcal IE pathogenesis were tested. In parallel, the genotypic profiles of all isolates, obtained by microarray, were analyzed by discriminant analysis of principal components (DAPC)((2)). No significant difference was observed between IE and bacteremia strains, regarding either phenotypic or genotypic univariate analyses. However, the multivariate statistical tool DAPC, applied on microarray data, segregated IE and bacteremia isolates: IE isolates were correctly reassigned as such in 80.6% of the cases (C-statistic 0.83, P<0.001). The performance of this model was confirmed with an independent French collection IE and bacteremia isolates (7...Continue Reading

References

Mar 1, 1993·Antimicrobial Agents and Chemotherapy·M R YeamanM A Ghannoum
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J S LiG R Corey
Jan 17, 2004·Lancet·Philippe Moreillon, Yok-Ai Que
Nov 17, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas PerpointJerome Etienne
Jan 16, 2007·Journal of Microbiological Methods·Patrick ChavantThierry Bernardi
Mar 11, 2009·Archives of Internal Medicine·David R MurdochUNKNOWN International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators
May 13, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S MoneckeR Ehricht
Jan 20, 2010·PLoS Medicine·Hajo GrundmannUNKNOWN European Staphylococcal Reference Laboratory Working Group
Aug 24, 2010·The Journal of Infectious Diseases·Jakub KwiecińskiMaria Bokarewa
Apr 14, 2011·Nature Reviews. Cardiology·Yok-Ai Que, Philippe Moreillon
Jun 21, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S Borrell, S Gagneux
Aug 17, 2011·The Journal of Infectious Diseases·Juhsien J C NienaberUNKNOWN International Collaboration on Endocarditis-Microbiology Investigators
Sep 20, 2011·Bioinformatics·Thibaut Jombart, Ismaïl Ahmed
Jan 17, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Ali J Marian
Apr 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christine Selton-SutyUNKNOWN AEPEI Study Group
Apr 26, 2013·Journal of Clinical Microbiology·Cara NethercottMark A Schembri
Apr 1, 2015·Nature Communications·Lucy A WeinertUNKNOWN BRaDP1T Consortium
May 13, 2015·Nature Communications·Lucy A WeinertUNKNOWN BRaDP1T Consortium
May 29, 2015·PloS One·Vincent Le MoingUNKNOWN VIRSTA study group

❮ Previous
Next ❯

Citations

May 15, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A BlomfeldtJ V Bjørnholt
Aug 16, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P BraquetUNKNOWN VIRSTA-AEPEI study group
Sep 15, 2016·Expert Review of Anti-infective Therapy·Stefano G GiulieriBenjamin P Howden
Sep 18, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S McNicholasD Fitzgerald-Hughes
Feb 13, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Elina JokinenJaana Syrjänen
Jun 26, 2018·Frontiers in Cellular and Infection Microbiology·Jean-Philippe RasigadeUNKNOWN AEPEI Study Group
Feb 28, 2018·BMC Microbiology·Oddvar OppegaardBård Reiakvam Kittang
Feb 8, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Rocío FalcónDavid Navarro
Nov 5, 2019·Frontiers in Medicine·Nadji HannachiLaurence Camoin-Jau
Feb 19, 2020·Nature Microbiology·Aleksandra Petrovic FabijanUNKNOWN Westmead Bacteriophage Therapy Team
Feb 23, 2018·Scientific Reports·Kirby R LattweinKlazina Kooiman
Sep 22, 2018·Frontiers in Cellular and Infection Microbiology·Emilia A BonarBenedykt Wladyka
May 10, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R San-JuanF Chaves
Dec 14, 2017·BMC Cardiovascular Disorders·Tadesse Melaku AbegazTamrat Befekadu Abebe
Jun 6, 2017·Frontiers in Microbiology·Dafne Pérez-MontareloFernando Chaves
Nov 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Feng JiangShoufa Han

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.