Staphylococcus aureus nasal carriage and infection in patients on hemodialysis. Efficacy of antibiotic prophylaxis

The New England Journal of Medicine
V L YuJ J Zuravleff

Abstract

We conducted a five-year prospective controlled study of prophylaxis of Staphylococcus aureus nasal carriage and infection among patients in a hemodialysis unit. Carriers tended to have chronic colonization with a single phage type. S. aureus infections occurred significantly more frequently in carriers than in noncarriers and, in 93 percent of the infected carriers, were caused by the same phage type as that carried in the nares. Neither intravenous vancomycin nor topical bacitracin was found to be efficacious in eradicating nasal carriage. However, oral rifampin given for five days decreased S. aureus carriage over a one-month follow-up period, but within three months colonization of the nares recurred in most carriers, often with an S. aureus of the original phage type. Carriers were then randomly assigned to receive either rifampin or no prophylaxis. Rifampin was readministered at three-month intervals if culture of the anterior nares yielded S. aureus. Infections with S. aureus occurred significantly more frequently in carriers given no prophylaxis than in those given a full course of rifampin. S. aureus resistant to rifampin was isolated from the anterior nares of four patients, but these isolates were not implicated in a...Continue Reading

References

Jan 1, 1978·Annals of Internal Medicine·J F DobkinN H Steigbigel
Jul 1, 1978·The American Journal of the Medical Sciences·C C LinnemannM C Laver
Jan 1, 1975·Journal of Clinical Pathology·M H RebelW C Noble
Mar 1, 1975·Antimicrobial Agents and Chemotherapy·M A Sande, G L Mandell
Apr 26, 1973·The New England Journal of Medicine·E G LowrieJ P Merrill
Aug 1, 1974·The British Journal of Dermatology·W C NobleI Smith
Aug 14, 1971·British Medical Journal·A J RalstonP Davis
Aug 1, 1971·The American Journal of the Medical Sciences·A J Morris, R T Bilinsky
Apr 11, 1970·British Medical Journal·J R DathanG R Youngs
Apr 1, 1984·Antimicrobial Agents and Chemotherapy·T P McAnallyD R Brown
Sep 1, 1982·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S E GoldblumW P Reed
Aug 1, 1981·The Journal of Infectious Diseases·L J WheatA WHITE
Jul 1, 1953·The Journal of Infectious Diseases·J E BLAIR, M CARR
Oct 16, 1954·British Medical Journal·L G TULLOCH
Sep 1, 1958·Annals of Internal Medicine·V KNIGHTM P MARTIN
Jun 25, 1959·The New England Journal of Medicine·H J WEINSTEIN
Jul 1, 1964·The American Journal of the Medical Sciences·A WHITE

Citations

Oct 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·C D HanevoldH J Baluarte
Jan 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B KuizonI B Salusky
May 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·X CorbellaF Gudiol
Nov 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T WeinkeH D Pohle
Jan 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L H Blumberg, K P Klugman
Apr 15, 2004·Indian Journal of Pediatrics·Jocelyn Y AngBasim I Asmar
Nov 16, 2002·Current Infectious Disease Reports·Fu-Yu Chiang, Michael Climo
Nov 13, 2004·Current Infectious Disease Reports·Philip M Polgreen, Loreen A Herwaldt
Sep 21, 2007·Current Infectious Disease Reports·Fredrick M Abrahamian, Eric W Snyder
Jan 2, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·A A AlghaithyA H Weily
Sep 26, 2001·Infectious Disease Clinics of North America·S Vas, D G Oreopoulos
Aug 23, 2001·International Journal of Antimicrobial Agents·M Kozioł-MontewkaM Majdan
Dec 1, 2001·Trends in Microbiology·S J PeacockFranklin D Lowy
Apr 26, 2007·Nature Clinical Practice. Nephrology·Ratnaja Katneni, S Susan Hedayati
Dec 17, 2005·Nature Reviews. Microbiology·E Yoko Furuya, Franklin D Lowy
Mar 23, 2011·Nature Reviews. Nephrology·Michiel G H Betjes
Oct 24, 2000·The British Journal of Surgery·G J MurphyM L Nicholson
Jan 22, 2003·Seminars in Dialysis·Jeffrey S Berns
Jun 1, 2004·Seminars in Interventional Radiology·Mary S Hammes
Jan 30, 1992·The New England Journal of Medicine·R P Wenzel
Aug 26, 1998·The New England Journal of Medicine·Franklin D Lowy
Jan 4, 2001·The New England Journal of Medicine·C von EiffG Peters
Oct 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L FierobeJ M Desmonts
Jun 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John J RossJames A Strom
Aug 31, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bianca QuagliarelloFranklin D Lowy
Nov 14, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lona ModySuzanne F Bradley
May 6, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jacques BaillargeonBrad H Pollock
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael W EllisClinton K Murray
May 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jose M EguiaHenry F Chambers
Jan 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·B N KreiswirthMichael Levi
Apr 11, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erica S ShenoyDavid C Hooper
May 20, 2009·The Journal of Antimicrobial Chemotherapy·T CoatesA Coates
May 27, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Georgia WinnettNeil Ashman
Jul 14, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kannaiyan S RabindranathAnatole Besarab
Jun 14, 2000·The Laryngoscope·Y H Goh, R L Goode
Oct 21, 2006·Current Opinion in Nephrology and Hypertension·Maarten W TaalChristopher W McIntyre

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.