Staphylococcus aureus requires increased level of Ca(2+) or Mn(2+) to grow normally in a high-NaCl/low-Mg(2+) medium

Microbiology and Immunology
T Ochiai


Mg2+-availability in Staphylococcus aureus cells decreased significantly with increasing NaCl concentration in growth media. Cells grew in a NaCl-free, Chelex resin-treated complex medium only if the medium was supplemented with 50 microM MgCl2, while, growth was limited when the medium was further supplemented with 1.0 M NaCl. Cells grown in such a high-NaCl/low-Mg2+ medium exhibited the morphologic abnormality of larger than normal cells. Both sufficient growth and normal cell morphology were restored by increasing Mg2+ concentration in a high-NaCl medium, or by supplementation with either CaCl2 or MnSO4 in a high-NaCl/low-Mg2+ medium. Supplementing with BaCl2, SrCl2 or FeSO4, however, had no effect. These results indicate that Ca2+ and Mn2+ might play some essential role in the growth of Staphylococcus aureus in a high-NaCl/low-Mg2+ environment.


Jun 1, 1976·Antimicrobial Agents and Chemotherapy·V Lorian, B Atkinson
Jan 1, 1987·Journal of Bacteriology·J C CortonJ Lutkenhaus
Nov 1, 1970·Journal of Bacteriology·M KojimaA Suganuma
Jan 1, 1967·Journal of Bacteriology·D Kennell, A Kotoulas
Jan 1, 1973·The Biochemical Journal·A H HughesJ Baddiley
Apr 1, 1970·Journal of Bacteriology·M KojimaK Hamada
Apr 1, 1980·Canadian Journal of Microbiology·A HurstR Pontefract
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A MukherjeeJ Lutkenhaus
Feb 28, 1998·The EMBO Journal·A Mukherjee, J Lutkenhaus

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