Staphylococcus aureus small colony variants in diabetic foot infections

Diabetic Foot & Ankle
Estrella Cervantes-GarcíaPaz Maria Salazar-Schettino

Abstract

Background : Staphylococcus aureus (S. aureus) is one of the major pathogens causing chronic infections. The ability of S. aureus to acquire resistance to a diverse range of antimicrobial compounds results in limited treatment options, particularly in methicillin-resistant S. aureus (MRSA). A mechanism by which S. aureus develops reduced susceptibility to antimicrobials is through the formation of small colony variants (SCVs). Infections by SCVs of S. aureus are an upcoming problem due to difficulties in laboratory diagnosis and resistance to antimicrobial therapy. Methods : A prospective study was performed on 120 patients diagnosed with both type 2 diabetes mellitus and infected diabetic foot ulcers. The study was carried out from July 2012 to December 2013 in Hospital General de Mexico. The samples were cultured in blood agar, mannitol salt agar, and MacConkey agar media, and incubated at 37°C in aerobic conditions. Results : We describe the first known cases of diabetic foot infections caused by MRSA-SCVs in patients diagnosed with type 2 diabetes mellitus and infected diabetic foot ulcers. In all of our cases, the patients had not received any form of gentamicin therapy. Conclusions : The antibiotic therapy commonly used i...Continue Reading

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Citations

Oct 9, 2015·Microbiology Insights·Benjamin E JohnsSarah E Maddocks
Sep 15, 2017·Diabetic Foot & Ankle·Estrella Cervantes-García, Paz María Salazar-Schettino
Mar 23, 2017·Pediatric Pulmonology·Rosemary CarzinoUNKNOWN AREST CF
Mar 11, 2016·Clinical Microbiology Reviews·Barbara C KahlBettina Löffler
Jul 29, 2021·Microbiology Spectrum·Dilair Camargo de SouzaJussara Kasuko Palmeiro
Sep 24, 2021·Frontiers in Microbiology·Jean-Philippe LavigneAlbert Sotto

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