Staphylococcus aureus Targets the Duffy Antigen Receptor for Chemokines (DARC) to Lyse Erythrocytes

Cell Host & Microbe
András N SpaanVictor J Torres

Abstract

In order for Staphylococcus aureus to thrive inside the mammalian host, the bacterium has to overcome iron scarcity. S. aureus is thought to produce toxins that lyse erythrocytes, releasing hemoglobin, the most abundant iron source in mammals. Here we identify the Duffy antigen receptor for chemokines (DARC) as the receptor for the S. aureus hemolytic leukocidins LukED and HlgAB. By assessing human erythrocytes with DARC polymorphisms, we determined that HlgAB- and LukED-mediated lysis directly relates to DARC expression. DARC is required for S. aureus-mediated lysis of human erythrocytes, and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis. HlgA and LukE bind directly to DARC through different regions, and by targeting DARC, HlgAB and LukED support S. aureus growth in a hemoglobin-acquisition-dependent manner. These findings elucidate how S. aureus targets and lyses erythrocytes to release one of the scarcest nutrients within the mammalian host.

References

Apr 1, 1995·Journal of Medical Microbiology·G PrevostY Piemont
Oct 1, 1994·Transfusion Medicine Reviews·K Wasniowska, T J Hadley
Jun 28, 2003·FEMS Microbiology Reviews·Simon C AndrewsFrancisco Rodríguez-Quiñones
Apr 23, 2004·Microbes and Infection·Eric P Skaar, Olaf Schneewind
Sep 14, 2004·Science·Eric P SkaarOlaf Schneewind
Nov 20, 2004·Nature Reviews. Microbiology·Ulrich E Schaible, Stefan H E Kaufmann
Apr 9, 2005·The New England Journal of Medicine·Scott K FridkinUNKNOWN Active Bacterial Core Surveillance Program of the Emerging Infections Program Network
Jul 19, 2005·Molecular and Biochemical Parasitology·Christophe TournamilleYves Colin
Oct 17, 2006·Journal of Bacteriology·Victor J TorresEric P Skaar
Dec 17, 2008·Nature Reviews. Microbiology·Kevin J Waldron, Nigel J Robinson
Jan 13, 2009·Infectious Disease Clinics of North America·Frank R DeLeoMichael Otto
Aug 15, 2009·Nature Reviews. Microbiology·Henry F Chambers, Frank R Deleo
Dec 15, 2010·Cell Host & Microbe·Gleb PishchanyEric P Skaar
Mar 30, 2012·PLoS Pathogens·Bas G J SurewaardJos A G van Strijp
Aug 25, 2012·Frontiers in Cellular and Infection Microbiology·François VandeneschThomas Henry
May 21, 2013·Cell Host & Microbe·James E Cassat, Eric P Skaar
May 21, 2013·Cell Host & Microbe·András N SpaanJos A G van Strijp
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ashley L DuMontVictor J Torres
Jun 25, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Alex J McCarthy, Jodi A Lindsay
Jul 10, 2013·Annual Review of Microbiology·András N SpaanJos A G van Strijp
Dec 18, 2013·The Journal of Infectious Diseases·Gleb PishchanyEric P Skaar
May 23, 2014·Microbiology and Molecular Biology Reviews : MMBR·Francis Alonzo, Victor J Torres

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Citations

Sep 12, 2015·Cell Host & Microbe·Adam J Ratner
Apr 20, 2017·Nature Reviews. Microbiology·András N SpaanVictor J Torres
Jan 10, 2019·Microbiology·Kyle D BuchanStephen A Renshaw
Dec 19, 2018·The Biochemical Journal·Nikolina TrstenjakAdriana Badarau
Jul 1, 2020·The Journal of Experimental Medicine·Kayan TamVictor J Torres
May 1, 2020·Frontiers in Microbiology·Angelino T Tromp, Jos A G van Strijp
May 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Karthigayan GunalanLouis H Miller
Jan 9, 2019·Frontiers in Microbiology·Tyler K NygaardJovanka M Voyich
Apr 11, 2018·The FEBS Journal·Catherine E Hughes, Robert J B Nibbs
Jan 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Xiaogang WangJean C Lee
Apr 5, 2020·International Journal of Molecular Sciences·Marialaura MarchettiLuca Ronda
Jan 18, 2019·Science Translational Medicine·Rita ChanVictor J Torres
Dec 29, 2018·British Journal of Haematology·Naama RappoportGideon Rechavi
Feb 2, 2021·Virulence·Gordon Y C CheungMichael Otto
Oct 15, 2020·The Journal of Biological Chemistry·Marilyn T VasquezVictor J Torres
Jan 18, 2021·The Journal of Biological Chemistry·Marilyn T VasquezVictor J Torres
Apr 16, 2021·Frontiers in Cellular and Infection Microbiology·Zhangchun GuanGuang Yang
Mar 16, 2019·Microbiology Spectrum·Kayan Tam, Victor J Torres
Mar 31, 2019·Microbiology Spectrum·Nienke W M de JongJos A G van Strijp

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