Staphylococcus epidermidis and biofilm-associated neutrophils in chronic rhinosinusitis. A pilot study

International Journal of Experimental Pathology
Janusz MarcinkiewiczAnna Tomusiak

Abstract

A key role of bacterial biofilm in the pathogenesis of chronic rhinosinusitis (CRS) with (CRSwNP) and without nasal polyps (CRSsNP) is commonly accepted. However, the impact of some bacterial species isolated from inflamed sinus mucosa on biofilm formation is unclear. In particular, the role of Staphylococcus epidermidis as aetiological agents of CRS is controversial. Moreover, the effect of biofilm formation on neutrophil infiltration and activity in CRSwNP calls for explanation. In this study, biofilms were found in three of 10 patients (mean age = 46 ± 14) with CRS undergoing endoscopic sinus surgery by means of scanning electron microscopy. Unexpectedly, S. epidermidis was the primary isolated bacteria and was also found to be present in all biofilm-positive mucosa specimens, indicating its pivotal role in the pathogenesis of severe chronic infections associated with biofilm formation. We have also measured the activity of myeloperoxidase (MPO), the most abundant neutrophil enzyme, to demonstrate the presence of neutrophils in the samples tested. Our present results show that the level of MPO in CRS associated with biofilm is lower than that without biofilm. It may suggest either a low number of neutrophils or the presence ...Continue Reading

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Citations

Jun 11, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Ioana Agache, Cezmi A Akdis
Aug 20, 2019·Current Medicinal Chemistry·Janusz Marcinkiewicz, Maria Walczewska
Mar 20, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Marta Ciszek-LendaJanusz Marcinkiewicz

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