PMID: 18406752Sep 1, 1996Paper

StAR-A tissue specific acute mediator of steroidogenesis

Trends in Endocrinology and Metabolism : TEM
B J Clark, D M Stocco

Abstract

The rate-limiting and acutely regulated step in steroid hormone biosynthesis is the translocation of cholesterol, the precursor of all steroid hormones, from the mitochondrial outer membrane to the inner membrane, where it is converted to pregnenolone by the cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc). This step has long been known to be dependent upon the de novo synthesis of a labile protein factor, which is required for the intramitochondrial translocation of cholesterol. Recently, the Steroidogenic Acute Regulatory (StAR) protein has been shown to have an indispensable role in acute steroid production and is proposed to be this labile protein factor. Given the fundamental importance of StAR as a key regulator of steroid hormone biosynthesis, the next frontier for researchers is elucidating the molecular mechanisms that control StAR expression and function.

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Citations

May 12, 2004·Molecular and Cellular Endocrinology·Alessandro M Capponi
Dec 24, 1997·Molecular and Cellular Endocrinology·B J Clark, D M Stocco
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·N Cherradi, A M Capponi
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Megumi HatoriYoshitaka Fukada
Apr 1, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Claude Fabre-NysRex J Scaramuzzi
Sep 23, 2016·Frontiers in Physiology·Gene A Morrill, Adele B Kostellow
May 2, 2013·American Journal of Physiology. Endocrinology and Metabolism·Yixin SuVictor M Pulgar
Jun 25, 2017·Clinical Science·Angela K Lucas-HeraldRhian M Touyz
Jul 24, 2015·The Journal of Clinical Endocrinology and Metabolism·Edra LondonConstantine A Stratakis
Jun 20, 2019·Biochemistry. Biokhimii︠a︡·K V Tugaeva, N N Sluchanko

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