Star-Shaped Intense Uptake of ¹³¹I on Whole Body Scans Can Reflect Good Therapeutic Effects of Low-Dose Radioactive Iodine Treatment of 1.1 GBq

Endocrinology and Metabolism
Sung Hye KongYoung Joo Park

Abstract

After initial radioactive iodine (RAI) treatment in differentiated thyroid cancer patients, we sometimes observe a star-shaped region of intense uptake of ¹³¹I on whole body scans (WBSs), called a 'star artifact.' We evaluated the clinical implications of star artifacts on the success rate of remnant ablation and long-term prognosis. Total 636 patients who received ¹³¹I dose of 1.1 GBq for the initial RAI therapy and who did not show distant metastasis at the time of diagnosis were retrospectively evaluated. A negative second WBS was used for evaluating the ablation efficacy of the RAI therapy. Among them, 235 patients (36.9%) showed a star artifact on their first WBS. In patients with first stimulated thyroglobulin (sTg) levels ≤2 ng/mL, patients with star artifacts had a higher rate of negative second WBS compared with those without star artifacts (77.8% vs. 63.9%, P=0.044), and showed significantly higher recurrence-free survival (P=0.043) during the median 8.0 years (range, 1.0 to 10.0) of follow-up. The 5- and 10-year recurrence rates (5YRR, 10YRR) were also significantly lower in patients with star artifacts compared with those without (0% vs. 4.9%, respectively, P=0.006 for 5YRR; 0% vs. 6.4%, respectively, P=0.005 for 10...Continue Reading

References

Nov 27, 1999·European Journal of Endocrinology·S FilettiM Schlumberger
Oct 21, 2000·Thyroid : Official Journal of the American Thyroid Association·E L Mazzaferri, R T Kloos
Feb 5, 2013·Thyroid : Official Journal of the American Thyroid Association·David F SchneiderRebecca S Sippel
Aug 29, 2014·European Journal of Endocrinology·Hoonsung ChoiBo Youn Cho
Oct 14, 2014·Endocrinology and Metabolism·June-Key Chung, Gi Jeong Cheon

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Citations

Dec 29, 2020·Revista española de medicina nuclear e imagen molecular·L XiaoL Li

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