PMID: 11906257Mar 22, 2002Paper

Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect

Bioconjugate Chemistry
Marek KovárB Ríhová

Abstract

The aim of this study was to compare the properties and antitumor potential of a novel type of antibody-targeted N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound doxorubicin conjugates with star structure with those of previously described classic antibody-targeted or lectin-targeted HPMA copolymer-bound doxorubicin conjugates. Classic antibody-targeted conjugates were prepared by aminolytic reaction of the multivalent HPMA copolymer containing side-chains ending in 4-nitrophenyl ester (ONp) reactive groups with primary NH(2) groups of the antibodies. The star structure of antibody-targeted conjugates was prepared using semitelechelic HPMA copolymer chains containing only one reactive N-hydroxysuccinimide group at the end of the backbone chain. In both types of conjugates, B1 monoclonal antibody (mAb) was used as a targeting moiety. B1 mAb recognizes the idiotype of surface IgM on BCL1 cells. The star structure of the targeted conjugate had a narrower molecular mass distribution than the classic structure. The peak in the star structure was around 300-350 kDa, while the classic structure conjugate had a peak around 1300 kDa. Doxorubicin was bound to the HPMA copolymer via Gly-Phe(D,L)-Leu-Gly spacer to ensure the contro...Continue Reading

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Citations

Apr 7, 2004·Advanced Drug Delivery Reviews·Karel Ulbrich, Vladimír Subr
Oct 22, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·M KovárB Ríhová
Jan 8, 2013·International Journal of Oncology·Yan-Jun ZhongYan Li
May 22, 2008·Expert Opinion on Drug Delivery·María J VicentAntonio Pineda-Lucena
Nov 22, 2005·Expert Opinion on Drug Delivery·Jin ChenIwao Ojima
Jan 31, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ela MarkovskyRonit Satchi-Fainaro
Aug 25, 2009·Advanced Drug Delivery Reviews·Ehud Segal, Ronit Satchi-Fainaro
Jan 12, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Twan LammersGert Storm
Jun 15, 2005·Scandinavian Journal of Immunology·B RihovaK Ulbrich
May 13, 2015·Molecular Therapy. Nucleic Acids·Breanne LandryHasan Uludag
Oct 30, 2007·ChemMedChem·Felix KratzAndré Warnecke
Jan 5, 2006·Pharmaceutical Research·Li Yan Qiu, You Han Bae
Jun 7, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Vlastimil MasekPavel Anzenbacher
Jun 18, 2019·Current Drug Metabolism·Selvan RavindranVedika Desai
Feb 14, 2021·Journal of Personalized Medicine·Petr ChytilTomáš Etrych
Jul 12, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eva RandárováTomáš Etrych
Mar 27, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Namdev DhasTejal Mehta

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