Starch microparticles as an adjuvant in immunisation: effect of route of administration on the immune response in mice

Vaccine
Linda StertmanIngvar Sjöholm

Abstract

This paper describes the effects on the development of an immune response by changing the route of administration of a new vaccine adjuvant, starch microparticles with human serum albumin (HSA) as a model antigen. The model vaccine was administered to mice by oral, subcutaneous and intramuscular routes in various combinations and both the local secretory immunoglobulin antibody (s-IgA) and systemic humoral and cellular (delayed-type hypersensitivity assay (DTH)) responses were followed. The only immunisation regimens inducing a significant s-IgA response were those incorporating oral booster doses. Oral and subcutaneous immunisations had similar effects on the Th1/Th2 balance, as indicated by the IgG subclass ratios and cytokine analyses. However, significant differences between oral and intramuscular immunisations were seen in the IgG subclass ratios. The Th2 influence was stronger after oral primary immunisation than after intramuscular primary immunisation, while oral boosters elicited a comparatively stronger Th1 response than intramuscular boosters. This result was also supported by the DTH analyses. Subcutaneous immunisation induced a stronger Th2 response than intramuscular immunisation, as indicated by subclass ratio an...Continue Reading

References

Nov 1, 1984·Journal of Pharmaceutical Sciences·P ArturssonI Sjöholm
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·R A Seder
Jan 1, 1994·Annual Review of Immunology·R A Seder, W E Paul
Jul 1, 1994·Medical Microbiology and Immunology·J F SchlaakB Fleischer
Jan 1, 1993·Annual Review of Immunology·S H Kaufmann
Jan 1, 1993·Annual Review of Immunology·F W FitchT F Gajewski
Oct 31, 1996·Nature·A K AbbasA Sher
Jan 1, 1997·Annual Review of Immunology·S L Constant, K Bottomly
Mar 4, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·S C ChattarajS K Das
Jan 20, 2000·Infection and Immunity·L BrandtP Andersen
Aug 30, 2000·Nature·A Aderem, R J Ulevitch
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·A OzinskyA Aderem

❮ Previous
Next ❯

Citations

Jul 27, 2012·Therapeutic Delivery·Jitinder WilkhuYvonne Perrie
Aug 6, 2014·International Journal of Pharmaceutics·S A Moreno-MendietaR Rodríguez-Sanoja
Oct 22, 2005·Nature Reviews. Immunology·Samir Mitragotri
Aug 3, 2010·Expert Review of Vaccines·Antonio GranellDiego Orzáez
Nov 26, 2009·Journal of Drug Targeting·Mohsen Tafaghodi, Somayeh Rastegar
Nov 2, 2006·Expert Opinion on Drug Delivery·Ed C Lavelle, D T O'Hagan
Nov 3, 2010·Journal of Drug Targeting·Barbara C Baudner, Derek T O'Hagan
Nov 22, 2005·Expert Opinion on Drug Delivery·George MutwiriLorne A Babiuk
Nov 22, 2005·Expert Opinion on Drug Delivery·Niclas RydellIngvar Sjöholm
Aug 16, 2008·Journal of Pharmaceutical Sciences·Jennifer H Wilson-WelderBalaji Narasimhan
May 2, 2012·International Journal of Pharmaceutics·Wei WangSandeep Nema
Sep 6, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Aziz AwaadKazunori Ishimura
Jun 10, 2008·International Journal of Pharmaceutics·S Abolghasem Sajadi TabassiMahmoud Reza Jaafari
Apr 29, 2014·Expert Review of Vaccines·Sergio Rosales-Mendoza, Jorge A Salazar-González
Nov 21, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Preeti KourAmit Kumar Goyal
Nov 11, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Donghong GaoDavid A Lawrence
Aug 18, 2006·The Journal of Pharmacology and Experimental Therapeutics·Elisabet GullbergPer Artursson
Jun 22, 2021·Expert Opinion on Drug Delivery·Pedro Gonzalez-Cruz, Harvinder Singh Gill
Mar 27, 2013·The Journal of Physical Chemistry. B·Wensheng LuWeiqiang Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.