Starch-quercetin conjugate by radical grafting: synthesis and biological characterization

Pharmaceutical Development and Technology
Giuseppe CirilloNevio Picci


A novel flavonoid-polysaccharide conjugate was synthesized by free radical grafting of quercetin on starch. The covalent insertion of quercetin in the polymeric chain was confirmed by FT-IR, DSC and fluorescence analyses, while an estimation of the amount of quercetin bound per g of polymer was obtained by the Folin-Ciocalteu assay. The conjugate shows improved UV stability and retains the antioxidant properties of free quercetin, such as scavenging activity towards free radicals (DPPH and peroxynitrite); inhibition of the free radical formation (peroxidation of linoleic acid) and total antioxidant activity. The conjugate also prevented drug degradation and shows potential health functionality in the treatment of Alzheimer disease, diabetes and as skin-whitening agent.


Jul 9, 1999·Journal of Biomedical Materials Research·C OrtizJ San Román
Feb 21, 2002·Pharmaceutical Development and Technology·Kenneth C WatermanChristopher J Roberts
Aug 21, 2003·Journal of Agricultural and Food Chemistry·Maria CareriIngrid Zagnoni
Mar 9, 2005·Current Opinion in Plant Biology·Matthew K Morell, Alan M Myers
Mar 17, 2005·Journal of Agricultural and Food Chemistry·Dejian HuangRonald L Prior
Jun 23, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·D Venkat RatnamM N V Ravi Kumar
Oct 20, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nuchanart RangkadilokJutamaad Satayavivad
Apr 14, 2007·The Journal of Pharmacy and Pharmacology·Francesca IemmaNevio Picci
Oct 27, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mankil Jung, Moonso Park
Dec 6, 2007·European Journal of Clinical Nutrition·J H Cummings, A M Stephen
Feb 5, 2008·Biotechnology Journal·Vidya Prabhakar Kodali, Ramkrishna Sen
Aug 6, 2008·Journal of Pharmaceutical and Biomedical Analysis·Yimei BaoHaoyun An
Nov 1, 2008·Journal of Agricultural and Food Chemistry·Francesco PuociNevio Picci
Dec 25, 2008·Phytotherapy Research : PTR·Wenli HouYuquan Wei
Feb 3, 2009·Journal of Agricultural and Food Chemistry·Joon-Kwan Moon, Takayuki Shibamoto
May 16, 2009·Journal of Pharmaceutical and Biomedical Analysis·Montserrat DueñasCelestino Santos-Buelga
Jul 8, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Natalia Quici, Marta I Litter
Aug 25, 2009·Journal of Hazardous Materials·R MeloL Wojnárovits
Aug 25, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·M J Santander-OrtegaC M Lehr
Feb 16, 2010·Talanta·Agnieszka Robaszkiewicz, Grzegorz Bartosz
Jul 6, 2010·Toxicology and Applied Pharmacology·Bhupendra SinghHari K Bhat
Jul 9, 2010·The Journal of Pharmacy and Pharmacology·Giuseppe CirilloNevio Picci
Nov 10, 2010·Biomacromolecules·Giuseppe CirilloFrancesca Iemma

❮ Previous
Next ❯


May 25, 2012·Pharmaceutical Research·Orazio VittorioNevio Picci
Jan 18, 2014·Journal of Drug Targeting·Orazio VittorioGiuseppe Cirillo
May 29, 2014·Critical Reviews in Food Science and Nutrition·Giuseppe CirilloNevio Picci
Oct 3, 2015·Carbohydrate Polymers·Sergey K FilippovNina S Domnina
Feb 8, 2018·Macromolecular Bioscience·Susan OliverCyrille Boyer
May 8, 2020·Pharmaceuticals·Gabriele CarulloFrancesca Aiello
Apr 10, 2019·Current Medicinal Chemistry·Iolanda Francolini, Antonella Piozzi
Nov 24, 2020·International Journal of Biological Macromolecules·Yu XiaoJingsheng Liu
Jan 1, 2017·Comprehensive Reviews in Food Science and Food Safety·Fuguo LiuDavid Julian McClements
Jan 23, 2021·International Journal of Biological Macromolecules·Huixia HuJun Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.