Starch-quercetin conjugate by radical grafting: synthesis and biological characterization

Pharmaceutical Development and Technology
Giuseppe CirilloNevio Picci

Abstract

A novel flavonoid-polysaccharide conjugate was synthesized by free radical grafting of quercetin on starch. The covalent insertion of quercetin in the polymeric chain was confirmed by FT-IR, DSC and fluorescence analyses, while an estimation of the amount of quercetin bound per g of polymer was obtained by the Folin-Ciocalteu assay. The conjugate shows improved UV stability and retains the antioxidant properties of free quercetin, such as scavenging activity towards free radicals (DPPH and peroxynitrite); inhibition of the free radical formation (peroxidation of linoleic acid) and total antioxidant activity. The conjugate also prevented drug degradation and shows potential health functionality in the treatment of Alzheimer disease, diabetes and as skin-whitening agent.

References

Jul 9, 1999·Journal of Biomedical Materials Research·C OrtizJ San Román
Feb 21, 2002·Pharmaceutical Development and Technology·Kenneth C WatermanChristopher J Roberts
Aug 21, 2003·Journal of Agricultural and Food Chemistry·Maria CareriIngrid Zagnoni
Mar 9, 2005·Current Opinion in Plant Biology·Matthew K Morell, Alan M Myers
Mar 17, 2005·Journal of Agricultural and Food Chemistry·Dejian HuangRonald L Prior
Jun 23, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·D Venkat RatnamM N V Ravi Kumar
Oct 20, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nuchanart RangkadilokJutamaad Satayavivad
Apr 14, 2007·The Journal of Pharmacy and Pharmacology·Francesca IemmaNevio Picci
Oct 27, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mankil Jung, Moonso Park
Dec 6, 2007·European Journal of Clinical Nutrition·J H Cummings, A M Stephen
Feb 5, 2008·Biotechnology Journal·Vidya Prabhakar Kodali, Ramkrishna Sen
Aug 6, 2008·Journal of Pharmaceutical and Biomedical Analysis·Yimei BaoHaoyun An
Nov 1, 2008·Journal of Agricultural and Food Chemistry·Francesco PuociNevio Picci
Dec 25, 2008·Phytotherapy Research : PTR·Wenli HouYuquan Wei
Feb 3, 2009·Journal of Agricultural and Food Chemistry·Joon-Kwan Moon, Takayuki Shibamoto
May 16, 2009·Journal of Pharmaceutical and Biomedical Analysis·Montserrat DueñasCelestino Santos-Buelga
Jul 8, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Natalia Quici, Marta I Litter
Aug 25, 2009·Journal of Hazardous Materials·R MeloL Wojnárovits
Aug 25, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·M J Santander-OrtegaC M Lehr
Feb 16, 2010·Talanta·Agnieszka Robaszkiewicz, Grzegorz Bartosz
Jul 6, 2010·Toxicology and Applied Pharmacology·Bhupendra SinghHari K Bhat
Jul 9, 2010·The Journal of Pharmacy and Pharmacology·Giuseppe CirilloNevio Picci
Nov 10, 2010·Biomacromolecules·Giuseppe CirilloFrancesca Iemma

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Citations

May 25, 2012·Pharmaceutical Research·Orazio VittorioNevio Picci
Jan 18, 2014·Journal of Drug Targeting·Orazio VittorioGiuseppe Cirillo
May 29, 2014·Critical Reviews in Food Science and Nutrition·Giuseppe CirilloNevio Picci
Oct 3, 2015·Carbohydrate Polymers·Sergey K FilippovNina S Domnina
Feb 8, 2018·Macromolecular Bioscience·Susan OliverCyrille Boyer
May 8, 2020·Pharmaceuticals·Gabriele CarulloFrancesca Aiello
Apr 10, 2019·Current Medicinal Chemistry·Iolanda Francolini, Antonella Piozzi
Nov 24, 2020·International Journal of Biological Macromolecules·Yu XiaoJingsheng Liu
Jan 1, 2017·Comprehensive Reviews in Food Science and Food Safety·Fuguo LiuDavid Julian McClements
Jan 23, 2021·International Journal of Biological Macromolecules·Huixia HuJun Liu

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