STARD13-correlated ceRNA network-directed inhibition on YAP/TAZ activity suppresses stemness of breast cancer via co-regulating Hippo and Rho-GTPase/F-actin signaling.

Journal of Hematology & Oncology
Lufeng ZhengTao Xi

Abstract

Targeting cancer stem cells is critical for suppressing cancer progression and recurrence. Finding novel markers or related pathways could help eradicate or diagnose cancer in clinic. By constructing STARD13-correlated ceRNA 3'UTR stable overexpression or knockdown breast cancer cells, we aimed to explore the effects of STARD13-correlated ceRNA network on breast cancer stemness in vitro and in vivo. Further RNA-sequencing was used to analyze transcriptome change in combination with functional studies on candidate signaling. Clinical samples obtained from The Cancer Genome Atlas data were used to validate the correlation between STARD13 and related pathways. Finally, in vitro and in vivo experiments were used to examine the effects of STARD13-correlated ceRNA network on chemotherapy sensitivity/resistance. Here, we revealed that this ceRNA network inhibited stemness of breast cancer. Mechanistically, we found that activation of STARD13-correlated ceRNA network was negatively correlated with YAP/TAZ activity in breast cancer. Specifically, this ceRNA network attenuated YAP/TAZ nuclear accumulation and transcriptional activity via collectively modulating Hippo and Rho-GTPase/F-actin signaling. Finally, we demonstrated that YAP/TAZ...Continue Reading

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Citations

Aug 3, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Lei JiangYue Zhang
Jan 30, 2020·Environmental Toxicology·Yunhe LuYiqun Cao
Dec 11, 2019·DNA and Cell Biology·Cong ZhangXiaotao Wu
Apr 28, 2020·The Journal of International Medical Research·Yuling GuoZhengyu Zhan
May 28, 2020·Journal of Hematology & Oncology·Yue YangLufeng Zheng
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Jun 27, 2021·Digestive Diseases and Sciences·Kai Nie, Mingquan Cai
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Aug 2, 2020·European Journal of Pharmacology·Qiong ZhaoLufeng Zheng

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Datasets Mentioned

BETA
GSE42568

Methods Mentioned

BETA
Transfection
PCR
confocal microscopy
GTPase
immunoprecipitation
RIP
Assay
flow cytometry
pull down
nuclear translocation

Software Mentioned

GO
Targetscan
Cuffdiff
TermFinder

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