Starting the cell cycle: what's the point?

Current Opinion in Cell Biology
F R Cross

Abstract

Early work on regulation of the budding yeast cell cycle defined a critical regulatory step called 'Start', considered to represent cell cycle commitment. Recent work has defined the probable molecular basis of Start to be activation of Cln-Cdc28 protein kinase complexes. Cln-Cdc28 kinases may directly regulate many cell cycle processes, including some classically considered to be 'post-Start'. Specialization of function among the three genetically redundant CLN genes is becoming apparent.

References

Sep 1, 1992·Genes & Development·C B Epstein, F R Cross
Nov 1, 1992·Genes & Development·H RichardsonS I Reed
Jun 27, 1991·Nature·L Dirick, K Nasmyth
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J A HadwigerS I Reed
Dec 22, 1989·Cell·H E RichardsonS I Reed
Feb 1, 1984·The Journal of Cell Biology·R A SingerG C Johnston
Dec 1, 1981·Experimental Cell Research·K GulløvB Bonven
Aug 1, 1995·Molecular and Cellular Biology·E A Vallen, F R Cross
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·R J Deshaies, M Kirschner
Mar 1, 1993·The Journal of Cell Biology·D J Lew, S I Reed
May 1, 1993·Genes & Development·J D McKinneyF R Cross
Apr 1, 1993·Current Opinion in Cell Biology·K Nasmyth

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Citations

Aug 10, 2006·Molecular Genetics and Genomics : MGG·José Pérez-MartínNatalia Carbó
Jan 13, 1998·Current Opinion in Cell Biology·M D Planas-Silva, R A Weinberg
Feb 1, 1997·Current Opinion in Genetics & Development·R J Deshaies
Apr 1, 1997·The International Journal of Biochemistry & Cell Biology·M Arellano, S Moreno
Aug 29, 2006·Oncogene·K Cooper
Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·G CharvinE D Siggia
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M Tyers
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y OdaB T Chait
Jan 26, 2002·Molecular Biology of the Cell·Frederick R CrossMartha Klovstad
Feb 13, 2001·Molecular Biology of the Cell·Z A Zimmerman, D R Kellogg
Oct 4, 2013·Molecular Biology of the Cell·Patricia A Pope, Peter M Pryciak
Sep 1, 1996·European Journal of Biochemistry·A Udvardy
Jun 10, 2000·Molecular and Cellular Biology·M D JacobsonF R Cross
Jun 10, 2000·Molecular and Cellular Biology·F R Cross, M D Jacobson
Aug 15, 2003·Molecular and Cellular Biology·Aparna SreenivasanDouglas R Kellogg
Apr 17, 2003·Molecular and Cellular Biology·Ethel Queralt, J Carlos Igual
Dec 2, 2004·Molecular and Cellular Biology·Brandt L SchneiderBruce Futcher
Jan 19, 1999·Annual Review of Microbiology·K Madden, M Snyder
Dec 14, 2012·Cell Division·Huzefa DungrawalaBrandt L Schneider
May 3, 2007·Journal of Biology·Arvind Ramanathan, Stuart L Schreiber
May 21, 2009·Journal of Cell Science·Jian-Bin WangMahasin A Osman
Aug 2, 2007·PloS One·Emmanuel J ChangTerry Gaasterland
Jun 23, 2011·PloS One·Catherine Oikonomou, Frederick R Cross
May 22, 2008·Genetics·Arkadi ManukyanBrandt L Schneider
Jul 17, 2010·Future Microbiology·Inês CorreiaJesús Pla
Aug 13, 1999·Molecular Cell·F R CrossM D Jacobson
Dec 20, 2005·The Journal of Investigative Dermatology. Symposium Proceedings·Jian ZhangBrandt L Schneider
Jan 3, 2006·Molecular Cell·James M BeanFrederick R Cross
Sep 17, 1998·Nature·B L SchneiderM Tyers

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