Startle-response based tasks and laboratory measures of impulsivity in abstinent alcoholic patients

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Marta MarinG Rubio

Abstract

It is well known that impulsivity is a risk factor for the development of Addictive Disorders, and more specifically Alcohol Use Disorders (AUD). Recently, the Startle-Response Based Tasks (SRBT) and its different forms of plasticity have been found to be impaired in the alcoholic population. This is the first study to explore the correlation between impulsivity laboratory tasks and the SRBT test, in order to determine whether impulsivity and startle response (SR) could be related and in turn, explain their association with Alcohol Dependence (AD). 40 men, who met DSM-IV criteria for AD and had been abstinent for at least one month. Impulsivity was assessed using three laboratory tests: Continuous Performance Test (CPT), Stop-Signal Task (SST) and Differential Reinforcement for Low-Rate Responding (DRL6). Patients also underwent the SR test. They were compared to 40 matched controls. Impulsivity laboratory measures tasks (SST and commissions of the CPT) correlated positively with the magnitude of SR (P < 0.05) and with habituation (P < 0.05). Scores on DRL6 correlated negatively with the magnitude of SR (P < 0.05). This was not found in the control group. The fact that impulsivity laboratory measures and the SR are correlated i...Continue Reading

References

Sep 1, 1988·Journal of Clinical Psychology·M Gordon, B B Mettelman
Dec 1, 1984·Journal of Abnormal Child Psychology·F D McClure, M Gordon
Dec 1, 1983·Journal of Abnormal Child Psychology·S H Klee, B D Garfinkel
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Jan 1, 1993·Psychopharmacology·C A MorganD S Charney
Feb 1, 1994·Psychopharmacology·C GrillonS S O'Malley
Sep 15, 1995·Biological Psychiatry·C A MorganD S Charney
Dec 1, 1996·Journal of Clinical and Experimental Neuropsychology·J C Ballard
Jul 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·C GrillonK R Merikangas
Nov 5, 1997·Alcoholism, Clinical and Experimental Research·K E HutchisonR Swift
Apr 30, 1999·Journal of the Experimental Analysis of Behavior·J B RichardsH de Wit
Aug 27, 1999·Progress in Neurobiology·M Koch
Feb 25, 2000·Biological Psychology·S GlautierA Williams
Apr 15, 2000·Pharmacology, Biochemistry, and Behavior·D L MckinzieA Shekhar
Aug 15, 2000·Drug and Alcohol Dependence·S D Lane, D R Cherek
Jun 19, 2001·Journal of Clinical and Experimental Neuropsychology·J N EpsteinC K Conners
Nov 27, 2001·Brain Research·M KoflerJ Valls-Solé
Mar 20, 2002·Addiction Biology·Paul A. KeedwellStuart A. Checkley
May 1, 2002·Alcoholism, Clinical and Experimental Research·Robert MirandaWilliam R Lovallo
Sep 17, 2002·European Psychiatry : the Journal of the Association of European Psychiatrists·S-M GrüsserH Flor
Oct 3, 2002·The American Journal of Psychiatry·Rita Z Goldstein, Nora D Volkow
Jan 30, 2003·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Andreas HeinzKarl Mann
Apr 5, 2003·Psychopharmacology·Kent E HutchisonTiffany Ito
Oct 1, 1956·Journal of Consulting Psychology·L H BECKI SARASON
Oct 24, 2003·Alcoholism, Clinical and Experimental Research·Theodora DukaDavid N Stephens
Dec 24, 2003·Alcoholism, Clinical and Experimental Research·Robert MirandaWilliam R Lovallo
Apr 16, 2004·Alcoholism, Clinical and Experimental Research·Caroline BrunelleRobert O Pihl
Dec 31, 2005·Alcoholism, Clinical and Experimental Research·Jennifer M MitchellCharlotte A Boettiger
Jan 13, 2006·Biological Psychology·Steven D LaRoweJohn P Kline
Feb 2, 2006·Biological Psychiatry·Luke ClarkBarbara J Sahakian
Apr 6, 2006·Behavioral and Cognitive Neuroscience Reviews·Eliza Congdon, Turhan Canli
Jun 20, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Geert DomBernard Sabbe
Jan 5, 2007·The American Journal of Psychiatry·Marc N Potenza
Mar 14, 2007·Emotion·Keith F DonohueAlan R Lang
Apr 25, 2007·Alcoholism, Clinical and Experimental Research·Gustavo D Barrenha, Julia A Chester

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