StartReact during gait initiation reveals differential control of muscle activation and inhibition in patients with corticospinal degeneration

Journal of Neurology
Bas J H van LithV Weerdesteyn

Abstract

Corticospinal lesions cause impairments in voluntary motor control. Recent findings suggest that some degree of voluntary control may be taken over by a compensatory pathway involving the reticulospinal tract. In humans, evidence for this notion mainly comes from StartReact studies. StartReact is the acceleration of reaction times by a startling acoustic stimulus (SAS) simultaneously presented with the imperative stimulus. As previous StartReact studies mainly focused on isolated single-joint movements, the question remains whether the reticulospinal tract can also be utilized for controlling whole-body movements. To investigate reticulospinal control, we applied the StartReact paradigm during gait initiation in 12 healthy controls and 12 patients with 'pure' hereditary spastic paraplegia (HSP; i.e., retrograde axonal degeneration of corticospinal tract). Participants performed three consecutive steps in response to an imperative visual stimulus. In 25% of 16 trials a SAS was applied. We determined reaction times of muscle (de)activation, anticipatory postural adjustments (APA) and steps. Without SAS, we observed an overall delay in HSP patients compared to controls. Administration of the SAS accelerated tibialis anterior and r...Continue Reading

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Citations

May 14, 2019·Disability and Rehabilitation·Hans C J W KerstensMaria W G Nijhuis-van der Sanden
Feb 6, 2020·The Journal of Physiology·Jumes Leopoldino Oliveira LiraCarla Silva-Batista
Nov 7, 2019·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Anthony N Carlsen, Dana Maslovat

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Software Mentioned

SPSS Statistics
StartReact
SAS

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