Starvation-induced proximal gut mucosal atrophy diminished with aging.

JPEN. Journal of Parenteral and Enteral Nutrition
Juquan SongM Jeschke

Abstract

Starvation induces small bowel atrophy with increased intestinal epithelial apoptosis and decreased proliferation. The authors examined these parameters after starvation in aged animals. Sixty-four 6-week-old and 26-month-old C57BL/6 mice were randomly assigned to either an ad libitum fed or fasted group. The small bowel was harvested at 12, 48, and 72 hours following starvation. Proximal gut mucosal height was measured and epithelial cells counted. Apoptosis was identified by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining. Proliferation was determined by immunohistochemical staining for proliferating cell nuclear antigen. Comparison of fed vs fasted and adult vs old groups was done by one-way ANOVA with Tukey's test and unpaired Student's t test. Significance was accepted at P < .05. Aged mice had higher proximal gut weights, mucosal heights, and cell numbers at baseline compared with the adult group (P < .05). The rate of apoptosis was lower in the aged (P < .05), but proliferation was not different between groups before starvation. After starvation, proximal gut wet weight decreased only in adult mice (P < .05). Gut mucosal height and mucosal cell number decreased more in adult than in...Continue Reading

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Citations

Nov 29, 2012·European Journal of Clinical Nutrition·A DiamantiM Gambarara
Jul 30, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Priscilla M UenoSean R Moore
Dec 1, 2012·World Journal of Gastroenterology : WJG·Darcy ShawMarc D Basson
Jul 8, 2010·The Journal of Surgical Research·Juquan SongMarc G Jeschke
Feb 8, 2013·European Eating Disorders Review : the Journal of the Eating Disorders Association·Miguel Angel Martínez-OlmosFelipe F Casanueva
Sep 18, 2012·Journal of Pediatric Gastroenterology and Nutrition·Reidun StenbergCurt Tysk
Nov 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Youli WangJianmin Yuan
Nov 3, 2020·The Journal of Poultry Science·Fumika Nanto-HaraMasaaki Toyomizu

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis